The Effect of Probiotics for <i>Helicobacter pylori</i>

Roh, Sun Hee; Shim, Ki Nam

doi:2011.11.1.26

Korean J Helicobacter Up Gastrointest Res > Volume 11(1); 2011 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2011;11(1):26-36.
DOI: https://doi.org/10.7704/kjhugr.2011.11.1.26 Published online June 10, 2011.

The Effect of Probiotics for Helicobacter pylori

Sun Hee Roh, Ki Nam Shim

Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea. shimkn@ewha.ac.kr

헬리코박터 파일로리에 대한 유산균의 효과

노선희, 심기남

이화여자대학교 의학전문대학원 내과학교실

Abstract

BACKGROUND/AIMS
Helicobacter pylori (H. pylori) infection is a major cause of chronic gastritis and peptic ulcer and a risk factor of gastric malignancy. Antibiotics based H. pylori eradication treatment is 90% effective, however, it is expensive and causes side effects and antibiotics resistance. Probiotics could present a low-cost, alternative solution to prevent or decrease H. pylori colonization. MATERIALS AND METHODS: Eligible articles were indentified by researches of electronic databases. RESULTS: In vitro studies demonstrated an inhibitory activity of probiotics on H. pylori growth and that this effect is extremely strain specific. The probiotics seem to be efficacious for the prevention of antibiotics associated side effects and might be of help for the prevention of H. pylori complications by decreasing H. pylori density and gastritis, and for the prevention of H. pylori colonization or re-infection by inhibiting adhesion to gastric epithelial cells. There was no significant evidence that probiotics may increase the H. pylori eradication rate. CONCLUSION: Probiotics could be an accessory treatment for H. pylori related gastric diseases, but more researches will be needed.

Key Words: Helicobacter pylori; Probiotics