Effect of Serotonergic Agent on Gastrointestinal Functions
Korean J Helicobacter Up Gastrointest Res 2010;10(1):6-13
Published online July 10, 2010
© 2010 Korean College of Helicobacter and Upper Gastrointestinal Research.

Mi-Young Kim, M.D. and Hwoon-Yong Jung, M.D., Ph.D.

Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Asan Digestive Disease Research Institute, Seoul, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the control of gastrointestinal (GI) motility, sensitivity, secretion, and regulation of cell growth by the receptors (5-HT1∼5-HT7) on enterocytes, instrinsic enteric neurons, extrinsic afferents, and smooth muscle cells. Functional GI disorder may relate to abnormal 5-HT activities in the gut and brain. Agonists and antagonists of several 5-HT receptor subtypes and agents that prevent 5-HT reuptake have documented benefits in functional GI disorder, however, their usefulness is underestimated by side effects which may or may not relate to their actions on 5-HT receptors. This review focuses on the effects of agents act on the serotonin receptor and agents that modulate serotonin uptake and synthesis and describes their therapeutic potential of these actions with side effects for functional GI disorder. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2010;10:6-13)
Keywords : Serotonin, Serotonin receptor, Selective serotonin reuptake inhibitor


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