Chemoprevention of Gastric Cancer: Helicobacter pylori Eradication
Korean J Helicobacter Up Gastrointest Res 2017;17(4):166-168
Published online December 10, 2017
© 2017 Korean College of Helicobacter and Upper Gastrointestinal Research.

Eun Jin Kim, Hang Lak Lee

Division of Gastroenterology, Department of Internal Medicine, Hanyang University Seoul Hospital, Seoul, Korea
Correspondence to: Hang Lak Lee
Division of Gastroenterology, Department of Internal Medicine, Hanyang University Seoul Hospital, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea
Tel: +82-2-2290-8354, Fax: +82-2-2298-9183, E-mail: alwayshang@hanyang.ac.kr
Received October 23, 2017; Revised November 6, 2017; Accepted November 7, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Gastric cancer is one of the most common fatal malignancies in the world, with a high incidence in Korea and Japan. Helicobacter pylori infection is an important factor in the pathogenesis of gastric cancer. Epidemiological studies have shown a strong causal relationship between H. pylori infection and gastric cancer. Animal studies have also shown that eradication of H. pylori infection, especially at the early stage, is effective in preventing H. pylori-related gastric carcinogenesis. H. pylori eradication leads to regression and prevents the progression of gastric precancerous lesions but only in a minority of cases. H. pylori eradication appears to be the most promising approach for gastric cancer prevention. The current available data from human studies show that H. pylori eradication can reduce the risk of developing gastric cancer, and this strategy is more useful in patients without atrophic gastritis or intestinal metaplasia. A longer follow-up and additional studies are needed for a better understanding of this issue.
Keywords : Chemoprevention; Helicobacter pylori; Stomach neoplasms


September 2018, 18 (3)
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