Chemoprevention of Gastric Cancer: Non-steroidal Anti-inflammatory Drugs Including Aspirin
Korean J Helicobacter Up Gastrointest Res 2017;17(4):169-174
Published online December 10, 2017
© 2017 Korean College of Helicobacter and Upper Gastrointestinal Research.

Kee Don Choi

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence to: Kee Don Choi
Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Tel: +82-2-3010-3180, Fax: +82-2-3010-6517, E-mail: Keedon@amc.seoul.kr
Received September 2, 2017; Revised October 26, 2017; Accepted October 31, 2017.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Many reports have been published that provide epidemiological evidence supporting the efficacy of aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) in cancer prevention. The presumed mechanism of chemoprevention is inhibition of cyclooxygenase (COX)-2. Aspirin exhibits an anticancerous effect through several inter-related mechanisms: prostaglandin synthesis and catabolism in epithelial cells, inhibition of Wnt-β‐catenin signaling, inactivation of platelets, and the host immune response. Several clinical studies have demonstrated that aspirin and NSAIDs exhibit chemopreventive effects in stomach cancer. However, well-designed clinical studies to answer critical clinical questions such as additional benefits of aspirin or NSAIDs after eradication of Helicobacter pylori, and the net benefit despite the adverse effects of long-term intake of aspirin or NSAIDs, are needed.
Keywords : Anti-inflammatory agents, non-steroidal; Aspirin; Chemoprevention; Stomach neoplasms


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