Liquid Biopsy: Current Status and Future Perspective in Gastric Cancer and Helicobacter Infection
Korean J Helicobacter Up Gastrointest Res 2018;18(3):150-156
Published online September 10, 2018
© 2018 Korean College of Helicobacter and Upper Gastrointestinal Research.

Eun A Kang1,2, Young Min Han1, Jong Min Park1, In Kyung Yoo2, Sung Pyo Hong2, Ki Baik Hahm1,2

CHA Bio Complex, CHA Cancer Prevention Research Center1, Digestive Disease Center, CHA Bundang Medical Center, CHA University School of Medicine2, Seongnam, Korea
Correspondence to: Ki Baik Hahm
Digestive Disease Center, CHA Bundang Medical Center, CHA University School of Medicine, 59 Yatap-ro, Bundang-gu, Seongnam 13496, Korea
Tel: +82-31-780-5000, Fax: +82-31-780-5000, E-mail:
Received April 4, 2018; Revised June 5, 2018; Accepted June 5, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Precision medicine stands for 4Ps – precise, preventive, participatory, and personal; in which “precision” is important because the current modern medicine starts from “trial and error,” and “one does not fit all”. Current targeted therapies for cancer have changed treatment approaches and led the precision medicine; however, clinical use of liquid biopsy, using blood or other liquid specimens to characterize circulating tumor cells (CTC) or tumor genes instead of biopsies of tumor tissues, still awaits availability of more information regarding non-invasive cancer detection and characterization, prediction of treatment response, monitoring the disease course and relapse possibilities, identification of mechanisms of drug resistance, and newer pathogenesis. In this review, we will introduce the basic concept of CTC, circulating cell free DNA, and exosomes and their possible application for gastric cancer relevant with Helicobacter pylori infection.
Keywords : Cell free DNA; Circulating tumor cell; Exosome; Gastric cancer; Liquid biopsy

December 2018, 18 (4)
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