Current Methods of Circulating Tumor Cell Detection
Korean J Helicobacter Up Gastrointest Res 2018;18(3):157-161
Published online September 10, 2018
© 2018 Korean College of Helicobacter and Upper Gastrointestinal Research.

Minji Lim1,2, Yoon-Kyoung Cho1,2

Department of Biomedical Engineering, School of Life Sciences, Ulsan National Institute of Science and Technology1, Center for Soft and Living Matter, Institute for Basic Science2, Ulsan, Korea
Correspondence to: Yoon-Kyoung Cho
Department of Biomedical Engineering, School of Life Sciences, Ulsan National Institute of Science and Technology, Center for Soft and Living Matter, Institute for Basic Science, 50 UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan 44919, Korea
Tel: +82-52-217-2511, Fax: +82-52-217-2509, E-mail: ykcho@unist.ac.kr
ORCID: https://orcid.org/0000-0001-6423-1834
Received March 28, 2018; Revised May 2, 2018; Accepted May 2, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA, and exosomes, offers a less invasive, new source of cancer-derived materials that may reflect the status of the disease better and thereby contribute to personalized treatment. Recent advances in microfluidics and molecular analysis technologies have resulted in greatly improved CTC enumeration and detection. In this article, we review commercially available technologies used to isolate CTCs from peripheral blood, including immunoaffinity and label-free, physical property-based isolation methods. Although enormous technological progress has been made, especially within the last decade, only a few CTC detection methods have been approved for routine clinical use. Here, we provide an overview of the current CTC isolation methods and examples of their potential application for early diagnosis, prognosis, treatment monitoring, and prediction of resistance to cancer therapy. Furthermore, the challenges that remain to be addressed before such tools are implemented for routine use in clinical settings are discussed.
Keywords : Circulating tumor cells; Liquid biopsy; Stomach cancer


September 2018, 18 (3)
Full Text(PDF) Free

Social Network Service
Services

Cited By Articles
  • CrossRef (0)