Change in the Prevalences and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia in Korea: Multicenter Clinical Trials
Korean J Helicobacter Up Gastrointest Res 2018;18(4):247-257
Published online December 10, 2018
© 2018 Korean College of Helicobacter and Upper Gastrointestinal Research.

Young-Jae Hwang1, Nayoung Kim1, Sung Eun Kim2, Gwang Ho Baik3, Ju Yup Lee4, Kyung Sik Park4, Young-Eun Joo5, Dae-Seong Myung5, Hyeon Ju Kim6, Hyun Joo Song7, Heung Up Kim7, Kwangwoo Nam8, Jeong Eun Shin8, Hyun Jin Kim9, Gwang Ha Kim10, Jongchan Lee1, Seon Hee Lim11, Geom Seog Seo12, Suck Chei Choi12

Department of Internal Medicine, Seoul National University Bundang Hospital1, Seongnam, Department of Internal Medicine, Kosin University College of Medicine2, Busan, Department of Internal Medicine, College of Medicine, Hallym University3, Chuncheon, Department of Internal Medicine, Keimyung University School of Medicine4, Daegu, Department of Internal Medicine, Chonnam National University Medical School5, Gwangju, Departments of Family Medicine6 and Internal Medicine7, Jeju National University School of Medicine, Jeju, Department of Internal Medicine, Dankook University College of Medicine8, Cheonan, Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine9, Jinju, Department of Internal Medicine, Pusan National University School of Medicine10, Busan, Department of Internal Medicine, Seoul National University Healthcare System Gangnam Center and Healthcare Research Institute11, Seoul, Department of Internal Medicine, Wonkwang University School of Medicine12, Iksan, Korea
Correspondence to: Nayoung Kim
Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea
Tel: +82-31-787-7008, Fax: +82-31-787-4051, E-mail: nayoungkim49@empas.com
Received July 23, 2018; Revised September 4, 2018; Accepted September 6, 2018.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research is an Open-Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background/Aims: The aim of this study was to analyze the trend of the prevalences of atrophic gastritis (AG) and intestinal metaplasia (IM) from 2011 to 2016∼2017 in Korea. And, the risk factors of AG and IM were compared between 2011 and 2016∼2017.
Materials and Methods: A total of 4,023 subjects in 2011 and 2,506 subjects in 2016∼2017 were enrolled. AG and IM were diagnosed on the basis of endoscopic findings. Multivariate analysis was performed for risk factors of AG and IM. Seventeen factors were analyzed.
Results: The seroprevalence of Helicobacter pylori decreased from 2011 (59.8%; 2,407/4,023) to 2016∼2017 (51.6%; 1,293/2,506; P< 0.001). The prevalence of AG decreased from 2011 to 2016∼2017 (P=0.018), but that of IM increased (P< 0.001). The risk factors of AG in 2011 were male sex, old age, H. pylori immuoglobulin G (IgG) positivity, family history of gastric cancer (GC), and high-salt diet. For IM in 2011, the risk factors were male sex, old age, H. pylori IgG positivity, and family history of GC. Risk factors of AG in 2016∼2017 were old age, H. pylori IgG positivity, and country of residence. For IM in 2016∼2017, the risk factors were male sex, old age, family history of GC, high fasting glucose level (≥126 mg/dL), H. pylori IgG positivity, and low income level.
Conclusions: The difference in prevalence trends of AG and IM between 2016∼2017 and 2011 could be the result of the different risk factors of AG and IM, such as decreased prevalence of H. pylori infection.
Keywords : Atrophic gastritis, Helicobacter pylori, Metaplasia, Prevalence, Risk factors


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