A Case of Asymptomatic Multiple Endocrine Neoplasia Type I with Thymic Carcinoid
Korean J Helicobacter Up Gastrointest Res 2019;19(1):65-70
Published online March 10, 2019
© 2019 Korean College of Helicobacter and Upper Gastrointestinal Research.

Suk Ki Park1, Moon Won Lee1, In Sub Han1, Young Joo Park1, Sung Yong Han1, Joon Woo Park1, Bong Eun Lee1, Gwang Ha Kim1,2, Sang Soo Kim1,2

Department of Internal Medicine, Pusan National University School of Medicine1, Biomedical Research Institute, Pusan National University Hospital2, Busan, Korea
Correspondence to: Moon Won Lee
Department of Internal Medicine, Pusan National University School of Medicine, and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea
Tel: +82-51-240-7869, Fax: +82-51-244-8180, E-mail: neofaceoff@hanmail.net
Received December 17, 2018; Revised February 12, 2019; Accepted February 12, 2019.
The Korean Journal of Helicobacter and Upper Gastrointestinal Research is an Open-Access Journal. All articles are distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Multiple endocrine neoplasia type 1 (MEN 1) is an autosomal dominant hereditary disorder caused by germline mutation of the MEN1 gene. It is characterized by tumors of the anterior pituitary gland, parathyroid glands, and endocrine pancreas. Thymic carcinoid tumor is uncommon and associated with a high mortality, but its natural history has not been investigated yet. We report a case of asymptomatic MEN 1 with a thymic carcinoid tumor. A 37-year-old man underwent a routine medical checkup and upper gastrointestinal endoscopy revealed a duodenal neuroendocrine tumor (NET). Further studies showed the coexistence of pancreatic tumor, parathyroid hyperplasia, pituitary adenoma, and thymoma. The patient underwent duodenal endoscopic mucosal resection, distal pancreatectomy, subtotal parathyroidectomy, and thymectomy. The pathological test revealed a duodenal NET, pancreatic NET, parathyroid hyperplasia, and thymic carcinoid tumor. He was treated for MEN 1. We report this asymptomatic case of MEN 1 with a literature review.
Keywords : Hyperparathyroidism; Multiple endocrine neoplasia type 1; Neuroendocrine tumors; Thymoma


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