A Rare Case of Gastric Carcinosarcoma with Neuroendocrine Differentiation

Shin, Hae Jin; Ju, Jong Seok; Moon, Hee Seok; Kang, Sun Hyung; Sung, Jae Kyu; Jeong, Hyun Yong; Song, Kyu Sang

doi:2014.14.2.121

Korean J Helicobacter Up Gastrointest Res > Volume 14(2); 2014 > Article

Case Report

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2014;14(2):121-125.
DOI: https://doi.org/10.7704/kjhugr.2014.14.2.121 Published online June 10, 2014.

A Rare Case of Gastric Carcinosarcoma with Neuroendocrine Differentiation

Hae Jin Shin, Jong Seok Ju, Hee Seok Moon, Sun Hyung Kang, Jae Kyu Sung, Hyun Yong Jeong, Kyu Sang Song

¹Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea. mhs1357@cnuh.co.kr
²Department of Pathology, Chungnam National University Hospital, Daejeon, Korea.

Abstract

Carcinosarcoma of the stomach is a rare biphasic tumor that consists of both carcinomatous and sarcomatous components. In the gastrointestinal tract, carcinosarcoma is most frequently seen in the esophagus and rarely in the stomach. Tubular or papillary adenocarcinomas are common carcinomatous components, whereas mesenchymal sarcomatous components may vary. Neuroendocrine carcinomatous differentiation in carcinomatous components is extremely rare. We report a 62-year-old female patient with a history of dyspepsia for one-month-history. Endoscopic findings showed a ulcerofungating lesion, which infiltrated from the posterior wall of the antrum to the posterior wall of the gastric angle. Radical subtotal gastrectomy was performed. In the resected specimen, immunohistochemical studies showed two positive reactions for epithelial and mesenchymal markers. Based on the above findings, the patient was diagnosed with a gastric carcinosarcoma with neuroendocrine differentiation.

Key Words: Carcinosarcoma; Stomach; Neuroendocrine differentiation factor, human; Immunohistochemistry