Liquid Biopsy: Current Status and Future Perspective in Gastric Cancer and <i>Helicobacter</i> Infection

Kang, Eun A; Han, Young Min; Park, Jong Min; Yoo, In Kyung; Hong, Sung Pyo; Hahm, Ki Baik

doi:2018.18.3.150

Korean J Helicobacter Up Gastrointest Res > Volume 18(3); 2018 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2018;18(3):150-156.
DOI: https://doi.org/10.7704/kjhugr.2018.18.3.150 Published online September 10, 2018.

Liquid Biopsy: Current Status and Future Perspective in Gastric Cancer and Helicobacter Infection

Eun A Kang, Young Min Han, Jong Min Park, In Kyung Yoo, Sung Pyo Hong, Ki Baik Hahm

¹CHA Bio Complex, CHA Cancer Prevention Research Center, Seongnam, Korea. hahmkb@cha.ac.kr
²Digestive Disease Center, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Korea.

액체 생검(Liquid Biopsy): 위암 및 헬리코박터 감염증에서 적응과 전망

강은아^1,2, 한영민¹, 박종민¹, 유인경², 홍성표², 함기백^1,2

CHA Bio Complex 차 암예방 연구센터¹, 차 의과학대학교 분당차병원 소화기센터²

Correspondence: Ki Baik Hahm, Tel: +82-31-780-5000, Fax: +82-31-780-5000,
Email: hahmkb@cha.ac.kr

Received: 4 April 2018 • Revised: 5 June 2018 • Accepted: 5 June 2018

Abstract

Precision medicine stands for 4Ps - precise, preventive, participatory, and personal; in which “precision” is important because the current modern medicine starts from “trial and error,” and “one does not fit all”. Current targeted therapies for cancer have changed treatment approaches and led the precision medicine; however, clinical use of liquid biopsy, using blood or other liquid specimens to characterize circulating tumor cells (CTC) or tumor genes instead of biopsies of tumor tissues, still awaits availability of more information regarding non-invasive cancer detection and characterization, prediction of treatment response, monitoring the disease course and relapse possibilities, identification of mechanisms of drug resistance, and newer pathogenesis. In this review, we will introduce the basic concept of CTC, circulating cell free DNA, and exosomes and their possible application for gastric cancer relevant with Helicobacter pylori infection.

Key Words: Cell free DNA; Circulating tumor cell; Exosome; Gastric cancer; Liquid biopsy