Sequential Therapy of <i>Helicobacter pylori</i> Infection

Kim, Jong In; Kim, Byung Wook

doi:2011.11.2.103

Korean J Helicobacter Up Gastrointest Res > Volume 11(2); 2011 > Article

Clinical Trial

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2011;11(2):103-111.
DOI: https://doi.org/10.7704/kjhugr.2011.11.2.103 Published online September 10, 2011.

Sequential Therapy of Helicobacter pylori Infection

Jong In Kim, Byung Wook Kim

Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine, Incheon, Korea. gastro@catholic.ac.kr

Helicobacter pylori의 순차적 제균 요법

김종인, 김병욱

가톨릭대학교 의과대학 인천성모병원 내과학교실 소화기내과

Abstract

The standard therapy for Helicobacter pylori infection in Korea consists of a triple-drug regimen containing a proton pump inhibitor with two antibiotics such as clarithromycin, amoxicillin, and metronidazole. However, the eradication rate of this regimen is declining and a new regimen should be prompted. Among them, sequential therapy seems to be more effective than the conventional triple therapy. Sequential therapy, however, has only been tried in the limited countries such as Italy. To recommend this therapy in clinical practice, well-designed clinical trials should be performed in Korea since many host factors and bacterial factors influence the treatment outcomes. In this article, we are going to review the basic concepts and the results of previous clinical trials on sequential therapy.

Key Words: Helicobacter pylori; Therapy