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Interleukin-1 Genetic Polymorphism in Helicobacter pylori Infection |
황일란 |
단국대학교 의과대학 소화기내과 |
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Abstract |
The scientific data on the role of cytokine genetic variation in gastric cancer risk is favorable. IL-1β and other cytokine polymorphisms could be a valuable predictive. no factor could be singled out to be most important for gastric cancer in H. pylori infection. Host-bacterial-environmental interaction is most likely to be involved in development of gastric cancer. Gastric cancer is the second most common cause of cancer-related deaths in the world. Assessing risk for gastric cancer is a big challenge but now becoming hopeful problem. The studies on host-bacterial-environmental interaction and gene-gene interaction indicated the promise of such approaches. I think that such approaches will be able to determine who is at greatest risk for H. pylori-associated gastric cancer. It will help us in the decision of whether or not treat the infection and who do endoscopy for cancer surveillance in East Asian countries where the prevalence of gastric cancer is high. |
Key Words:
Genetic polymorphism, Helicobacter pylori, Gastric cancer |
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