Association of Polymorphism of IL-10 and TNF-A Genes with Gastric Cancer in Korea

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2004;4(2):40-46.
Published online December 30, 2004.

한국인에서 IL-10과 TNF-A 유전자 다형성과 위암 발생

이자영·김학양·김경호·김성만* 이준호·장명국·박준용·이진헌 김진호^†·유재영

한림대학교 의과대학 내과학교실, *강동성심병원 소화기연구실, ^†울산대학교 의과대학 내과학교실

Abstract

Background/Aims: We performed this study to determine the role of polymorphisms of the IL-10 and TNF-α promoter genes in the carcinogenesis/ pathogenesis of gastric cancer (GC) in Korea. Methods: A total of 232 patients with GC (n=122), gastric ulcer (GU)(n=58), and duodenal ulcer (DU) (n=52) were enrolled and 120 healthy controls were included. Polymorphisms of IL-10- 1082/-592 gene and TNF-A-308 gene were genotyped by PCR-RFLP. Results: There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group with GC or PUD and control group. In addition, there was no difference in genotypic frequencies according to the H. pylori infection status and histologic type of GC. Conclusions: In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2004;4:40-46)

Key Words: Gastric cancer, Interleukin-10, Tumor necrosis factor-alpha, Polymorphism, Helicobacter pylori