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Korean J Helicobacter  Up Gastrointest Res > Volume 13(1); 2013 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2013;13(1):30-35.
DOI: https://doi.org/10.7704/kjhugr.2013.13.1.30    Published online March 10, 2013.
The Antisecretory Therapy Improves Anxiety and Depression Symptoms in Patients with Symptomatic Gastroesophageal Reflux Disease
Tae Wan Kim, Woo Ho Ban, Su Jeong Kim, Seung Jee Ryu, Sung Eun Ha, Ji Woong Rho, Bong Han Kong, Ji Hyun Kim, Eun Hee Kim, Jung Hwan Oh
Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea. ojh@catholic.ac.kr
증상이 있는 위식도역류질환 환자의 위산분비억제치료 후 호전된 불안 우울증상
김태완, 반우호, 김수정, 류승지, 하성은, 노지웅, 공봉한, 김지현, 김은희, 오정환
가톨릭대학교 의과대학 내과학교실
Anxiety and depression are associated with reflux symptoms in patients with gastroesophageal reflux disease (GERD). The purpose of this study is to investigate whether the anxiety and depression in patients with GERD will improve with anti-secretory treatment. MATERIALS AND METHODS: Participants who had taken upper endoscopic evaluation and who had symptoms of heartburn or acid regurgitation more than once a week were included through questionnaires. The hospital anxiety and depression scale was used to compare the scores before and after anti-secretory drug (proton pump inhibitor [PPI] or histamine-2 receptor blocker [H2 blocker]) treatment for four weeks. RESULTS: Eighty-four out of a total 94 patients were randomly assigned to a four week treatment, in which, 46 and 38 patients were each assigned to PPI and H2 blocker, respectively. Regardless of the type of treatment, anxiety scores decreased significantly from 5.8+/-3.8 to 5.2+/-3.9 after treatment (P=0.033). Depression scores of 6.3+/-3.4 before treatment reduced to 5.5+/-3.4 after treatment (P=0.011). Anxiety scores and depression scores decreased significantly after treatment in the H2 blocker group. In the response group, anxiety and depression showed significant improvement (P=0.008, P=0.011). CONCLUSIONS: Regardless of the type of drugs, anti-secretory therapy is helpful in treating symptomatic GERD patients, not only in relieving symptoms, but also in relieving anxiety and depression accompanied with GERD.
Key Words: Gastroesophageal reflux; Anxiety; Depression; Proton pump inhibitors; Histamine H2 antagonists
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