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Korean J Helicobacter  Up Gastrointest Res > Volume 15(3); 2015 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2015;15(3):160-165.
DOI: https://doi.org/10.7704/kjhugr.2015.15.3.160    Published online September 10, 2015.
Eradication Rates of First-line and Second-line Therapy for Helicobacter pylori Infection in Gyeongnam Province
Gyo Hui Kim, Jin Ah Kim, Ui Won Ko, Jong Ho Park, Jue Yong Lee, Su Sin Jin, Yeon Ho Joo, Jae Uk Shin
1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
2Department of Internal Medicine, Changwon Fatima Hospital, Changwon, Korea. jushin1000@naver.com
경남 지역 Helicobacter pylori 1차 및 2차 제균 치료의 제균율 변화
김교희, 김진아, 고의원, 박종호1, 이주용1, 진수신1, 주연호1, 신재욱1
가톨릭대학교 의과대학 내과학교실, 창원파티마병원 내과1
Abstract
BACKGROUND/AIMS
The eradication rates of Helicobacter pylori has been decreasing over the years and it is different among the regions. The aim of this study was to investigate the rates of first-line and the second-line eradication of H. pylori over the last 5 years in a single institute of Changwon and Gyeongsangnam-do, Korea. MATERIALS AND METHODS: Eradication rates of first-line triple regimen in 1,164 patients and second-line quadruple regimen in 223 patients who received H. pylori eradication treatment from January 2008 to December 2012 at Changwon Fatima Hospital were evaluated retrospectively. The patients for second-line quadruple therapy were divided into three groups according to the dosage of medications. RESULTS: The overall eradication rates of first-line and second-line therapy were 70.5% and 81.2%, respectively. There was no decreasing tendency in the eradication rate of first-line therapy for 5 years (P=0.573). However, annul eradication rates of second-line therapy significantly decreased (P=0.001, linear by linear association). In second-line therapy, patients treated with high dose bismuth and metronidazole had higher eradication rates than those treated with low dose bismuth and metronidazole (P=0.039). CONCLUSIONS: The effectiveness of the first-line and second-line therapy for H. pylori was suboptimal. In addition, there was a decreasing tendency in the eradication rates of second-line therapy over the past 5 years in Changwon and Gyeongsangnam-do province. Alternative regimens or high dose therapy should be considered for first-line and second-line therapy.
Key Words: Helicobacter pylori; Eradication


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