Vaccine Development and Future for <i>Helicobacter pylori</i>

Cho, Soo Jeong

doi:2016.16.3.134

Korean J Helicobacter Up Gastrointest Res > Volume 16(3); 2016 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2016;16(3):134-138.
DOI: https://doi.org/10.7704/kjhugr.2016.16.3.134 Published online September 10, 2016.

Vaccine Development and Future for Helicobacter pylori

Soo Jeong Cho

Center for Gastric Cancer, National Cancer Center, Goyang, Korea. crystal522@ncc.re.kr

Helicobacter pylori 백신 개발 현황과 전망

조수정

국립암센터 위암센터

Abstract

Helicobacter pylori is one of the most common gastric pathogens, affecting at least half the world's population, and is strongly associated with gastritis, peptic ulcer, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Vaccination against H. pylori has been challenging because of its low efficacy, lack of information about protective immunity, and disappointing clinical studies. A recent phase 3 clinical trial in China was reported to be successful to test prophylactic vaccination against H. pylori, which caused growing interest in the vaccine development against H. pylori. Here, we review literatures regarding vaccination against H. pylori.

Key Words: Helicobacter pylori; Vaccine