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Korean J Helicobacter  Up Gastrointest Res > Volume 16(1); 2016 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2016;16(1):13-18.
DOI: https://doi.org/10.7704/kjhugr.2016.16.1.13    Published online March 10, 2016.
Is Endoscopic Resection for Type 1 Gastric Neuroendocrine Tumors Essential for Treatment?: Multicenter, Retrospective Long-term Follow-up Results
Han Sol Lee, Seong Woo Jeon, Gwang Ha Kim, Jin Il Kim, Il Kwun Chung, Sam Ryong Jee, Heung Up Kim, Geom Seog Seo, Gwang Ho Baik, Kee Don Choi, Jeong Seop Moon
1Department of Internal Medicine, Kyungpook National University Medical Center, Daegu, Korea. swjeon@knu.ac.kr
2Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
3Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
4Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea.
5Department of Internal Medicine, Inje University Pusan Paik Hospital, Busan, Korea.
6Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
7Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University College of Medicine, Iksan, Korea.
8Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
9Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
10Department of Internal Medicine, Inje University Seoul Paik Hospital, Seoul, Korea.
Abstract
BACKGROUND/AIMS
Treatment of gastric neuroendocrine tumors is determined by type and size of the lesion. This study aimed to compare the long-term efficacy of observation and endoscopic resection for type 1 gastric neuroendocrine tumors without metastasis. MATERIALS AND METHODS: Among the 223 cases of gastric neuroendocrine tumors diagnosed between January 1996 and December 2011, 104 cases were type 1 gastric neuroendocrine tumors. Sixty-seven patients were treated endoscopically and 27 patients were observed without treatment. Endoscopic mucosal resection, endoscopic submucosal dissection, and polypectomy were the methods used for endoscopic treatment. Therapeutic efficacy and rates of complication and recurrence were evaluated retrospectively. RESULTS: In the endoscopic resection group, complete resection was observed in 53 patients (79.1%), and recurrence was observed in 14 patients (20.9%). On analysis of the observation group, no change was observed in 19 patients (70.4%), and tumor progression was observed in 8 patients (29.6%). Median follow-up duration was 49 months (31~210 months). No mortality was reported in either group during follow-up. CONCLUSIONS: Observation of type 1 gastric neuroendocrine tumors without metastasis yields results similar to those produced by endoscopic resection. Observation alone may be a safe treatment.
Key Words: Stomach; Neuroendocrine tumors; Endoscopy; Observation; Treatment
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