Trend in the Eradication Rates of <i>Helicobacter pylori</i> Infection in the Last 8 Years in Daegu: A Single Center Experience

Kim, Si Hye; Jung, Jin Tae; Kwon, Joong Goo; Kim, Eun Young; Kang, Sun Mi; Song, Jeong Eun

doi:2015.15.4.236

Korean J Helicobacter Up Gastrointest Res > Volume 15(4); 2015 > Article

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2015;15(4):236-242.
DOI: https://doi.org/10.7704/kjhugr.2015.15.4.236 Published online December 10, 2015.

Trend in the Eradication Rates of Helicobacter pylori Infection in the Last 8 Years in Daegu: A Single Center Experience

Si Hye Kim, Jin Tae Jung, Joong Goo Kwon, Eun Young Kim, Sun Mi Kang, Jeong Eun Song

Department of Internal Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. jungjt@cu.ac.kr

대구 단일기관에서 최근 8년간의 Helicobacter pylori 제균율 변화

김시혜, 정진태, 권중구, 김은영, 강선미, 송정은

대구가톨릭대학교 의과대학 내과학교실

Abstract

BACKGROUND/AIMS
Helicobacter pylori eradication rates achieved by first-line triple treatment with proton pump inhibitor (PPI), clarithromycin, and amoxicillin have decreased to 70~85%, in part due to increasing antimicrobial resistance. This study evaluated the trend in H. pylori eradication rates during the most recent 8 years in Daegu, Korea and analyzed different clinical factors between success group and failure group of H. pylori eradication. MATERIALS AND METHODS: This was a retrospective study at a single institution. A total of 768 H. pylori-positive patients who received one or two weeks of first-line triple regimens were included between January 2007 and October 2014. RESULTS: The overall H. pylori eradication rate was 86%. The eradication rate from years 2007 to 2014 was 80.5%, 89.4%, 95.6%, 85.5%, 87.9%, 75.8%, 83.3%, and 85.8%, respectively (P=0.027). There was no significant difference in the eradication rate among various PPIs (P=0.358). In addition, there were no significant difference of clinical factors between success and failure group of H. pylori eradication. CONCLUSIONS: The eradication rates of first-line triple therapy for H. pylori over 8 years were 75.8~95.6%. No significant difference in clinical factors were noted between success and failure group of H. pylori eradication. Triple therapy may be a useful regimen for H. pylori eradication in Daegu.

Key Words: Helicobacter pylori; Disease eradication