Efficacy of Ecabet Sodium for <i>Helicobacter pylori</i> Eradication with Sequential Therapy

So, Seol; Ahn, Ji Yong; Na, Hee Kyong; Jung, Kee Wook; Lee, Jeong Hoon; Kim, Do Hoon; Choi, Kee Don; Song, Ho June; Lee, Gin Hyug; Jung, Hwoon Yong

doi:2018.18.3.180

Korean J Helicobacter Up Gastrointest Res > Volume 18(3); 2018 > Article

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2018;18(3):180-185.
DOI: https://doi.org/10.7704/kjhugr.2018.18.3.180 Published online September 10, 2018.

Efficacy of Ecabet Sodium for Helicobacter pylori Eradication with Sequential Therapy

Seol So, Ji Yong Ahn

, Hee Kyong Na, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon Yong Jung

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. ji110@hanmail.net

순차치료에 병합 투여된 Ecabet Sodium이 Helicobacter pylori 제균에 미치는 효과

소  설, 안지용, 나희경, 정기욱, 이정훈, 김도훈, 최기돈, 송호준, 이진혁, 정훈용

울산대학교 의과대학 서울아산병원 소화기내과

Correspondence: Ji Yong Ahn, Tel: +82-2-3010-5667, Fax: +82-2-476-0824,
Email: ji110@hanmail.net

Received: 14 April 2018 • Revised: 8 May 2018 • Accepted: 8 June 2018

Abstract

BACKGROUND/AIMS
We aimed to compare the outcomes of Helicobacter pylori eradication in patients receiving sequential therapy (ST) depending on the use of ecabet sodium (ES). MATERIALS AND METHODS: Between January to December 2015, 176 patients randomly received either ST alone (n=72) or 10-day ES therapy combined with ST (n=104). After applying the exclusion criteria, 56 patients were finally assigned to the ST-only group and 84 to the ST with ES group. We retrospectively reviewed and analyzed the H. pylori eradication rate and adverse events between the two groups. RESULTS: Among the 140 patients, 121 (86.4%) achieved successful H. pylori eradication and 24 (17.1%) had adverse events. Eradication was achieved in 50 patients (89.3%) in the ST-only group and in 71 patients (84.5%) in the ST with ES group (P=0.420). No significant difference in the incidence of adverse events was found between the ST-only and ST with ES groups (12.5% vs. 20.2%, respectively; P=0.234). However, the ST with ES group tended to have a higher prevalence of nausea or vomiting than the ST-only group (11.9% vs. 1.8%; P=0.050). CONCLUSIONS: ST showed a good H. pylori eradication rate without deteriorating the adverse events regardless of adding ES.

Key Words: Ecabet sodium; Helicobacter pylori; Sequential therapy