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Korean J Helicobacter  Up Gastrointest Res > Volume 15(2); 2015 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2015;15(2):112-116.
DOI: https://doi.org/10.7704/kjhugr.2015.15.2.112    Published online June 10, 2015.
Ten Years Retrospective Study about Helicobacter pylori Eradication Rate
Gyung Won Jeong, In Kyung Sung
Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea. 20050051@kuh.ac.kr
Helicobacter pylori 제균치료 성공률의 변화에 대한 10년간의 후향적 연구
정경원, 성인경
건국대학교 의학전문대학원 내과학교실
Abstract
BACKGROUND/AIMS
Eradication of Helicobacter pylori is a main treatment of peptic ulcer disease. A triple therapy comprised of a proton pump inhibitor, clarithromycin, and amoxicillin is the most commonly used treatment for H. pylori eradication. The eradication of H. pylori infection requires combination of antibiotics. However, development of antibiotic resistance is a major cause of treatment failure. MATERIALS AND METHODS: This study was to observe H. pyrori eradication rate change for 10 years. From August 2005 to June 2014, a total of 4,891 patients with H. pylori infection were treated with standard H. pylori triple eradication therapy (proton pump inhibitor, amoxicillin, clarithromycin) and were analyzed by urea breath test. RESULTS: The overall rates of eradication with standard triple therapy was 82.8% (4,048/4,891). H. pylori eradication rates decreased from 92.2% in 2005 to 80.2% in 2014 (P=0.037). CONCLUSIONS: This study shows that the overall rate of H. pylori eradication with standard triple therapy decreased meaningfully for 10 years.
Key Words: Helicobacter pylori; Standard triple therapy; Eradication rate


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