Recent First Line Eradication Rate of <i>Helicobacter pylori</i> Infection: Single Center Experience

Shin, Seung Min; Lim, Yun Jeong; Yoon, Yeo Jin; Kang, Hyoun Woo; Kim, Jae Hak; Lee, Jun Kyu; Koh, Moon Su; Lee, Jin Ho

doi:2015.15.2.108

Korean J Helicobacter Up Gastrointest Res > Volume 15(2); 2015 > Article

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2015;15(2):108-111.
DOI: https://doi.org/10.7704/kjhugr.2015.15.2.108 Published online June 10, 2015.

Recent First Line Eradication Rate of Helicobacter pylori Infection: Single Center Experience

Seung Min Shin, Yun Jeong Lim, Yeo Jin Yoon, Hyoun Woo Kang, Jae Hak Kim, Jun Kyu Lee, Moon Su Koh, Jin Ho Lee

Division of Gastroenterology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea. drlimyj@gmail.com

최근 Helicobacter pylori 감염의 일차 제균 치료 성적: 단일 병원 경험

신승민, 임윤정, 윤여진, 강현우, 김재학, 이준규, 고문수, 이진호

동국대학교일산병원 소화기내과

Abstract

BACKGROUND/AIMS
For more than a decade, triple therapy (proton pump inhibitor, amoxicillin, clarithromycin) has been the first line eradication regimen for Helicobacter pylori infection in Korea. However, recent studies have proven that its' efficacy is no longer tolerable due to increased resistance of antibiotics. This study is aimed to investigate the current status of triple therapy, quadruple therapy and dual therapy as first line regimen for H. pylori infection in single medical center. MATERIALS AND METHODS: Medical records of patients who received urea breath test after first line eradication therapy from August 2011 to November 2014 were retrospectively analyzed. Patients were divided into three groups according to the first line treatment regimen; triple therapy (proton pump inhibitor (PPI)+clarithromycin+amoxicillin), quadruple therapy (PPI+bismuth+tetracycline+metronidazole), dual therapy (PPI+amoxicillin). RESULTS: A total of 557 patients were reviewed and 429 patients (77.0%) had successful eradication. Among 511 patients who received triple therapy, the eradication rates were 77.1% (394 patients). Eradication rates were 95.2% among quadruple therapy group. Dual therapy group had exceptionally low eradication rates (60.0%). CONCLUSIONS: Even though triple therapy has been recommended as first line regimen in Korea, eradication rates were below 80%. Quadruple therapy as first line regimen showed promising future reaching over 90% eradication rates. However, due to the small number of patients in our study, further studies are necessary to estimate usefulness of quadruple therapy as first line regimen.

Key Words: Helicobacter pylori; Eradication; Triple therapy; Quadruple therapy