<i>Helicobacter pylori</i> Infection and Food Intervention for Preventing Associated Gastric Diseases Including Gastric Cancer

Chung, Mi Kyung; Kim, Hye Sung; Park, Jong Min; Kim, Eun Hee; Han, Young Min; Kwon, Sung Hun; Park, Kun Young; Hahm, Ki Baik

doi:2014.14.4.225

Korean J Helicobacter Up Gastrointest Res > Volume 14(4); 2014 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2014;14(4):225-232.
DOI: https://doi.org/10.7704/kjhugr.2014.14.4.225 Published online December 10, 2014.

Helicobacter pylori Infection and Food Intervention for Preventing Associated Gastric Diseases Including Gastric Cancer

Mi Kyung Chung, Hye Sung Kim, Jong Min Park, Eun Hee Kim, Young Min Han, Sung Hun Kwon, Kun Young Park, Ki Baik Hahm

¹Cancer Prevention Research Center, CHA University, Seoul, Korea. hahmkb@cha.ac.kr
²Department of Food and Science and Nutrition, Pusan National University, Busan, Korea.
³Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Helicobacter pylori 감염과 음식을 통한 연관질환 완화 및암예방적 접근

정미경¹, 김혜성¹, 박종민¹, 김은희¹, 한영민¹, 권성훈¹, 박건영², 함기백^1,3

차의과학대학교 암예방 연구센터¹, 부산대학교 식품영양학과², 차의과학대학교 분당차병원 소화기내과³

Abstract

Since the discovery of Helicobacter pylori infection as the major cause of gastroduodenal disorders including acute and chronic gastritis, gastroduodenal ulcer, chronic atrophic gastritis, and gastric malignancy almost three decades ago, the possibility of preventing these clinical diseases through eradication has been the focus of active research and debate, especially since eradication can prevent cancer. Eradication intervenes with the initiation and progression of mucosal atrophy, metaplasia, dysplasia and gastric cancer. Our group hypothesized that nutritional interventions can rejuvenate the atrophic mucosa and ameliorate H. pylori-associated gastric inflammation. In this review article, the experience and outcomes regarding nutritional applications to rejuvenate gastric atrophy will be introduced. Korean red ginseng, garlic extracts, cancer preventive Korea Kimchi, n-3 polyunsaturated fatty acids, special form of licorice, and probiotics will be reviewed. The detailed effects of dietary and bacterial eradication therapy on disease progression and lesion reversibility are discussed.

Key Words: Helicobacter pylori; Gastritis; Rejuvenation; Carcinogenesis; Prevention & control