Helicobacter pylori Infection and Food Intervention for Preventing Associated Gastric Diseases Including Gastric Cancer |
Mi Kyung Chung, Hye Sung Kim, Jong Min Park, Eun Hee Kim, Young Min Han, Sung Hun Kwon, Kun Young Park, Ki Baik Hahm |
1Cancer Prevention Research Center, CHA University, Seoul, Korea. hahmkb@cha.ac.kr 2Department of Food and Science and Nutrition, Pusan National University, Busan, Korea. 3Department of Gastroenterology, CHA Bundang Medical Center, CHA University, Seongnam, Korea. |
Helicobacter pylori 감염과 음식을 통한 연관질환 완화 및암예방적 접근 |
정미경1, 김혜성1, 박종민1, 김은희1, 한영민1, 권성훈1, 박건영2, 함기백1,3 |
차의과학대학교 암예방 연구센터1, 부산대학교 식품영양학과2, 차의과학대학교 분당차병원 소화기내과3 |
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Abstract |
Since the discovery of Helicobacter pylori infection as the major cause of gastroduodenal disorders including acute and chronic gastritis, gastroduodenal ulcer, chronic atrophic gastritis, and gastric malignancy almost three decades ago, the possibility of preventing these clinical diseases through eradication has been the focus of active research and debate, especially since eradication can prevent cancer. Eradication intervenes with the initiation and progression of mucosal atrophy, metaplasia, dysplasia and gastric cancer. Our group hypothesized that nutritional interventions can rejuvenate the atrophic mucosa and ameliorate H. pylori-associated gastric inflammation. In this review article, the experience and outcomes regarding nutritional applications to rejuvenate gastric atrophy will be introduced. Korean red ginseng, garlic extracts, cancer preventive Korea Kimchi, n-3 polyunsaturated fatty acids, special form of licorice, and probiotics will be reviewed. The detailed effects of dietary and bacterial eradication therapy on disease progression and lesion reversibility are discussed. |
Key Words:
Helicobacter pylori; Gastritis; Rejuvenation; Carcinogenesis; Prevention & control |
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