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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2018;18(3):157-161.
DOI: https://doi.org/10.7704/kjhugr.2018.18.3.157    Published online September 10, 2018.
Current Methods of Circulating Tumor Cell Detection
Minji Lim, Yoon Kyoung Cho 
1Department of Biomedical Engineering, School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Korea. ykcho@unist.ac.kr
2Center for Soft and Living Matter, Institute for Basic Science, Ulsan, Korea.
순환종양세포 검출 기술
임민지1,2, 조윤경1,2
울산과학기술원 생명과학부 생명공학과1, 기초과학연구원 첨단연성물질연구단2
Correspondence:  Yoon Kyoung Cho, Tel: +82-52-217-2511, Fax: +82-52-217-2509, 
Email: ykcho@unist.ac.kr
Received: 28 March 2018   • Revised: 2 May 2018   • Accepted: 2 May 2018
Liquid biopsy, the analysis of circulating biomarkers from peripheral blood, such as circulating tumor cells (CTCs) and circulating tumor DNA, and exosomes, offers a less invasive, new source of cancer-derived materials that may reflect the status of the disease better and thereby contribute to personalized treatment. Recent advances in microfluidics and molecular analysis technologies have resulted in greatly improved CTC enumeration and detection. In this article, we review commercially available technologies used to isolate CTCs from peripheral blood, including immunoaffinity and label-free, physical property-based isolation methods. Although enormous technological progress has been made, especially within the last decade, only a few CTC detection methods have been approved for routine clinical use. Here, we provide an overview of the current CTC isolation methods and examples of their potential application for early diagnosis, prognosis, treatment monitoring, and prediction of resistance to cancer therapy. Furthermore, the challenges that remain to be addressed before such tools are implemented for routine use in clinical settings are discussed.
Key Words: Circulating tumor cells; Liquid biopsy; Stomach cancer
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