Immune Response to <i>Helicobacter pylori</i> Infection

Han, Jae Pil; Hong, Su Jin

doi:2013.13.4.220

Korean J Helicobacter Up Gastrointest Res > Volume 13(4); 2013 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2013;13(4):220-223.
DOI: https://doi.org/10.7704/kjhugr.2013.13.4.220 Published online December 10, 2013.

Immune Response to Helicobacter pylori Infection

Jae Pil Han, Su Jin Hong

Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea. sjhong@schmc.ac.kr

헬리코박터 파일로리 감염의 면역

한재필, 홍수진

순천향대학교 의과대학 내과학교실

Abstract

Helicobacter pylori infection leads to immune responses associated with almost all mechanism of innate and acquired immunity. However, clinical manifestation of H. pylori infection varies from asymptomatic gastritis to gastric cancer. The balance between harmful injury in gastric mucosa and protective role of immune mechanisms may be influenced by the variability of bacterial virulence factors, host susceptibility, and environmental factors. In this review, we describe the inflammatory response of H. pylori infection and protective mechanism against H. pylori infection. Better understanding of the mechanism of the immune response to H. pylori infection can be helpful in the development of new therapeutic strategies and prophylactic vaccine.

Key Words: Helicobacter pylori; Immunity