대한Helicobacter 연구학회지 Search

CLOSE


대한Helicobacter 연구학회지 2001;1(1):22-25.
Published online December 30, 2001.
Marginal Zone B-cell Lymphoma of MALT
점막 변연부 B-세포 림프종
고영혜
성균관의대 삼성서울병원 진단병리과
Abstract
MALT lymphoma is a unique type of extranodal lymphoma which is associated with Helicobactor pylori. Polyclonal B cells proliferating in the chronic Helicobactor gastritis are evolved into monoclonal population through the antigen selection and somatic mutation. Several factors, including BCL10, API2-MALT1, p53, c-myc, and DCC, have been implicated as genetic steps in the transformation of low grade lymphoma to an aggressive lymphoma. In addition to molecular markers, morphologic and immunologic factors including presence of large cell cluster, number of scattered large cells, and loss of costimulatory molecules such as CD86, CD80, CD40, and their ligands can reflect antigen- independent phase of low grade lymphoma. BCL10 and API2-MALT are characteristic genetic alteration of MALT lymphoma and associated with advanced MALT lymphoma. Their oncogenic activities may be related to each other, but the precise mechanism underlying the molecular interaction between BCL10 and API2-MALT1 and the functional consequence of such an interaction remain to be investigated. (Korean J Helicobacter Res Prac 2001;1:22-25)
Key Words: Helicobactor, Lymphoma, MALT, Stomach
TOOLS
Share :
Facebook Twitter Linked In Google+ Line it
METRICS Graph View
  • 718 View
  • 7 Download
Related articles in Korean J Helicobacter Up Gastrointest Res


Editorial Office
Lotte Gold Rose II Room 917, 31 Seolleung-ro 86-gil, Gangnam-gu, Seoul 06193, Korea
Tel: +82-2-717-5543    Fax: +82-2-565-9947    E-mail: kjhugr@kams.or.kr                

Copyright © 2024 by Korean College of Helicobacter and Upper Gastrointestinal Research.

Developed in M2PI

Close layer
prev next