Korean J Helicobacter  Up Gastrointest Res Search


The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2001;1(1):22-25.
Published online December 30, 2001.
Marginal Zone B-cell Lymphoma of MALT
점막 변연부 B-세포 림프종
성균관의대 삼성서울병원 진단병리과
MALT lymphoma is a unique type of extranodal lymphoma which is associated with Helicobactor pylori. Polyclonal B cells proliferating in the chronic Helicobactor gastritis are evolved into monoclonal population through the antigen selection and somatic mutation. Several factors, including BCL10, API2-MALT1, p53, c-myc, and DCC, have been implicated as genetic steps in the transformation of low grade lymphoma to an aggressive lymphoma. In addition to molecular markers, morphologic and immunologic factors including presence of large cell cluster, number of scattered large cells, and loss of costimulatory molecules such as CD86, CD80, CD40, and their ligands can reflect antigen- independent phase of low grade lymphoma. BCL10 and API2-MALT are characteristic genetic alteration of MALT lymphoma and associated with advanced MALT lymphoma. Their oncogenic activities may be related to each other, but the precise mechanism underlying the molecular interaction between BCL10 and API2-MALT1 and the functional consequence of such an interaction remain to be investigated. (Korean J Helicobacter Res Prac 2001;1:22-25)
Key Words: Helicobactor, Lymphoma, MALT, Stomach
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