Korean J Helicobacter  Up Gastrointest Res Search

CLOSE


The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2001;1(1):26-30.
Published online December 30, 2001.
Helicobacter pylori Infection and the Cell Cycle
Helicobacter pylori 감염과 세포주기
장세진
한양대학교 의과대학 병리학교실
Abstract
Experimental evidences of association between Helicobacter pylori infection and gastric carcinoma are increasing. Recent evidences suggest that expression of various molecules enrolled in cell cycle machinery in gastric epithelial cells are affected by H. pylori infection resulting in change of cell proliferation and cell death. Loss of growth control is a characteristic of malignant cells. Unconstrained proliferation can be largely explained by the gain or loss of function of protein that constitute the cell cycle machinery itself. Almost all human cancers are found to have mutations in one or another of the genes involved in controlling cell cycle. The derangement of cell cycle in H. pylori infected gastric epithelial cell may be a molecular mechanism of Helicobacter-induced gastric carcinogenesis. In this review, molecular mechanism of cell cycle control will be discussed. (Korean J Helicobacter Res Prac 2001;1:26-30)
Key Words: Cell cycle control, Gastric carcinogenesis, Helicob


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR AUTHORS
FOR REVIEWERS
Editorial Office
Lotte Gold Rose II Room 917, 31 Seolleung-ro 86-gil, Gangnam-gu, Seoul 06193, Korea
Tel: +82-2-565-9946    Fax: +82-2-565-9947    E-mail: hpylori@kams.or.kr                

Copyright © 2021 by Korean College of Helicobacter and Upper Gastrointestinal Research.

Developed in M2PI

Close layer
prev next