Treatment of <I>Helicobacter pylori </I>Infection in the Secondary and Tertiary Hospitals

대한Helicobacter 연구학회지 2001;1(1):68-70.
Published online December 30, 2001.

Treatment of Helicobacter pylori Infection in the Secondary and Tertiary Hospitals

2, 3차 의료기관에서의 Helicobacter pylori 감염의 치료

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울산의대 서울중앙병원 소화기내과

Abstract

Helicobacter pylori(H. pylori) can induce many diseases such as peptic ulcer, low-grade MALT lymphoma and chronic gastritis. The recurrence of peptic ulcer was markedly decreased after eradication therapy for H. pylori. Low-grade MALT lymphoma is also associated with H. pylori infection. Eradication therapy can induce histologic remission in the patients with MALT lymphoma stage IE. In general, the indications for eradication therapy are H. pylori-infected peptic ulcer disease and low-grade MALT lymphoma. Recommended second-line regimen used in the patients with failing eradication therapy for H. pylori is PPI plus classic triple(bismuth, tetracycline, metronidazole) regimen. It is necessary to perform repeated endoscopy with biopsy for the patients with gastric ulcer as well as those with low-grade MALT lymphoma to confirm histology and H. pylori status. Standard regimen for the eradication therapy is PPI-based triple therapy including two antibiotics especially clarithromycin. For the patients with persistent infection after eradication, quadruple therapy including PPI and classic triple regimen may be recommended. (Korean J Helicobacter Res Prac 2001;1:68-70)

Key Words: Eradication, Helicobacter pylori, MALT lymphoma, Peptic ulcer