Association between <em>Helicobacter pylori</em> Infection and the Risk of Gastric Cancer Among the Korean People: Prospective Case-controlled Study

Original

대한Helicobacter 연구학회지 2002;2(1):18-24.
Published online June 21, 2002.

Association between Helicobacter pylori Infection and the Risk of Gastric Cancer Among the Korean People: Prospective Case-controlled Study

한국인에서 Helicobacter pylori 감염과 위암 위험도에 관한 전향적 환자-대조연구

장웅기·김학양·김용범·김동준·이 진·박충기·유재영

한림대학교 의과대학 내과학교실

Abstract

Background/Aims: We conducted a prospective case-controlled study matched and adjusted by age, sex, education and economic status to evaluate the causal relationship between H. pylori infection and gastric cancer among Korean people. Methods: From March 1997 to October 1998, consecutive 136 gastric cancer patients diagnosed by endoscopic histology and 136 age and sex matched control subjects confirmed to be free from gastric cancer by endoscopy during the same period were selected. The presence of H. pylori infection was determined by EIA serology test. Results: Seventy-two patients(53%) of the 136 gastric cancer patients were positive for H. pylori infection and 54(40%) of the 136 control subjects were positive for H. pylori infection. The odds ratio(OR) adjusted by variable risk factors such as age, sex, education and economic status for gastric cancer in H. pylori infected patients was 1.82(95% CI, 1.10∼3.00, P=0.019). And age and sex matched OR by conditional logistic regression was 1.6(95% CI, 1.01∼2.53, P=0.043). Conclusions: H. pylori infection might be one of the important risk factors for the development of gastric cancer in Korea, the area of high prevalence of H. pylori infection and high incidence rate of gastric cancer. (Korean J Helicobacter Res Prac 2002;2:18-24)

Key Words: Gastric cancer, Helicobacter pylori