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대한Helicobacter 연구학회지 2002;2(2):188-191.
Published online November 21, 2002.
The Eradication Effect of One-week Esomeprazole Based Triple Therapy in Duodenal Ulcer Patients
십이지장 궤양 환자에서 1주간의 Esomeprazole 포함 삼제 병합 요법의 Helicobacter pylori 제균 효과
홍수진·정인섭·유창범·김진오·조주영·이준성·이문성·심찬섭·김부성
순천향대학교 의과대학 내과학교실, 소화기연구소
Abstract

Background/Aims: Proton pump inhibitor-based triple therapy is the most commonly used H. pylori eradication regimen. Esomeprazole, a new proton pump inhibitor that is the S-isomer of omeprazole, has been shown to be metabolized at a lower rate, resulting in higher plasma levels. We compare the efficacy of esomeprazole and omeprazole for the eradication for H. pylori in patients with duodenal ulcer. Methods: One hundred and forty eight duodenal ulcer patients with H. pylori infection were treated with esomeprazole 20 mg twice daily or omeprazole 20 mg twice daily, in combination with amoxicillin 1,000 mg and clarithromycin 500 mg twice daily for 7 days. The successful H. pylori eradication was confirmed by a negative 13C-urea breath test from 4 weeks to 6 weeks after completing therapy. Results: H. pylori eradication rates were comparable for esomeprazole vs. omeprazole(ITT: 90.5% vs. 83.8%; PP: 91.8% vs. 86.1%). The differences in eradication rates were not statistically significant between both groups. No withdrawal due to side-effects were identical in the two groups. Conclusions: Esomeprazole-based triple therapy for 7 days is effective therapy of H. pylori eradication in the patients with duodenal ulcer, and is well tolerated. (Korean J Helicobacter Res Prac 2002;2:188-191)

Key Words: Helicobacter pylori, Esomeprazole, Triple therapy
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