<b>The Effects of The Green Tea Extract on <em>Helicobacter pylori</em> Infection</b>

대한Helicobacter 연구학회지 2003;3(2):146-152.
Published online November 30, 2003.

The Effects of The Green Tea Extract on Helicobacter pylori Infection

Helicobacter pylori 감염시 녹차추출물(Green Tea Extract, EGCG)의 위질환 보호효과

이기명·박수진·임선교·이은희 조정선·이정상*·서영준*·김용석^† 김진홍· 조성원·함기백

아주대학교 의과대학 소화기내과학교실, 간 및 소화기질환 유전체 연구센터, *서울대학교 약학대학 생화학교실 및 ^†한양대학교 의과대학 생화학교실

Abstract

Helicobacter pylori infection is associated with diverse upper gastrointestinal diseases, such as peptic and duodenal ulcers as well as gastric cancer. Really longstanding period of infection impose great risk of H. pylori-related gastric disease, based on the evidence that early childhood infection is responsible for ensuing atrophic gastritis and gastric cancer related to H. pylori infection. Green tea is known to be profitable for heath for a long time. The components of green tea are known to be catechins and include epigallocatechin-3-gallate(EGCG), epicatechin gallate(ECG). EGCG has been known to inhibit several pro-inflammatory cytokines, cyclooxygenase and lipoxygenase, nitric oxide synthase, TNF-α, xanthine oxidase, and nuclear factor κB(NF-κB). In animal model of alcohol induced gastritis, EGCG has a significant mucosa protective effect with modulation of COX-2, interleukin, NF-κB, MARK signaling molecule. In AGS cell line infected with H. pylori ATCC43504 strain. EGCG has decreased TLR-2, TLR-2, and TLR-4 expression in immunohistochemical study. EGCG also inhibited the expression of TNF-α and apoptosis at dose-dependent pattern. We can conclude that anti-inflammatory and anti-apoptosis effect of EGCG is mediated with attenuated expression of p38, p-JNK signaling, IL-8, iNOS, and NF-κB. These experimental results support the beneficial efficacy of green tea in H. pylori infection.

Key Words: H. pylori, EGCG, AGS, NF-κB, IL-8