Korean J Helicobacter  Up Gastrointest Res Search


The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2004;4(1):21-24.
Published online June 30, 2004.
The Eradication Rate of Helicobacter pylori Infection in Complicated Peptic Ulcer Diseases
합병증을 동반한 소화성 궤양 환자에서 Helicobacter pylori의 제균율
고려대학교 의과대학 내과학교실
Background/Aims: Helicobacter pylori(H. pylori) is present in more than 90% of peptic ulcer patients. Substantial evidences suggest that eradication of the infection improves the ulcer healing and reduces the complications. The aim of this study was to evaluate the eradication rate of H. pylori in complicated peptic ulcer diseases. Methods: From April 1999 through April 2003, 89 complicated peptic ulcer patients(hemorrhage, perforation, obstruction) with H. pylori infection were enrolled. H. pylori infection was analyzed by rapid urease test, 13C-urea breath test and histologic examination. The patients were treated with PPI based triple therapy for 7∼14 days. One month after completion of therapy, 13C-urea breath test, histologic examination or rapid urease test was performed to confirm eradication. Results: The eradication rate of H. pylori in the patients with complicated peptic ulcer diseases was 79.8%(71 of 89), which was not significantly different from that of patients with uncomplicated peptic ulcer diseases, 85.1%(361 of 424, p=0.089). Conclusions: The eradication rate of H. pylori infection in complicated peptic ulcer diseases is not significantly different from that of uncomplicated peptic ulcer diseases. (Korean J Helicobacter Upper Gastrointest Res 2004;4:21-24)
Key Words: Peptic ulcer, Complication, Helicobacter pylori, Eradication rate

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