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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2006;6(1):23-28.
Published online June 1, 2006.
Eradication Rate of Helicobacter pylori according to Host Factors and Treatment Regimen
소화성 궤양 환자에서 숙주요인과 투여된 약제에 따른 Helicobacter pylori 제균율
허원석·강선형·김정일·채경훈 정재훈·강윤세·김연수·김석현·성재규·이병석·정현용
충남대학교 의과대학 소화기내과학교실
Abstract
Background/Aims: Infection with H. pylori occurs worldwide, but the prevalence varies greatly among countries and population groups within the same country. It is suggested that H. pylori infection is influenced by environmental and host factors (sex, age, smoking, drinking, eating habits, genetics, acid secreting capability and Lewis blood type). We assessed the eradication rates according to the host factors, types of diseases (GU vs. DU) and treatment regimen, retrospectively. Methods: From January 2003 to February 2005, 280 peptic ulcer patients with H. pylori infection were enrolled. H. pylori infection was assessed by CLO test, histologic examination or urea breath test before the treatment and 4∼8 weeks after the cessation of the treatment of proton pump inhibitor-based 7-day regimen (rabeprazole 10 mg b.i.d. or lansoprazole 30 mg b.i.d. or omeprazole 20 mg b.i.d. with amoxicillin 1 g b.i.d., clarithromycin 500 mg b.i.d.). RAC group comprised 165 cases, while LAC group 61 cases and OAC group 31 cases, respectively. Secondary regimens in patients who failed to respond to primary regimens were PPI with BCT (bismuth 600 mg q.i.d, clarithromycin 500 mg b.i.d, tetracycline 500 mg q.i.d) or PPI with BMT (bismuth 600 mg q.i.d, metronidazole 500 mg t.i.d, tetracycline 500 mg q.i.d). Patient information for host factors was obtained by chart review and telephone interview. Results: The overall eradication rate was 80.3%. Eradication rate of LAC group was 83.6%, while RAC group 80.0%, OAC group 71.0% respectively. The overall eradication rate of secondary regimens was 78.5%. Eradication rate of PPI with BCT group was 46.2% and that of PPI with BMT was 93.1%. There was no significant difference in the eradication rates according to the age, sex, drinking, ABO blood type and the presence of diabetes mellitus. However, there was a significant difference in the eradication rate according to the smoking. Non-smoker group showed siguificant superior eradication rate compare to smoking group (85.5% vs 75.8%, p=0.042). Conclusions: LAC regimen shows higher eradication rate than OAC regimen, however, there was no statistical significance (83.6% vs. 71.0%, p=0.157). In secondary eradication, PPI with BMT regimen is superior to PPI with BCT regimen (93.1% vs. 46.2%, p=0.001). Smoking was significant factor associated with H. pylori eradication. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2006;6:23-28)
Key Words: Helicobacter pylori, Eradication rate


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