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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2006;6(1):18-22.
Published online June 1, 2006.
Analysis of Cardiovascular Risk Factors in Health Screening Adults with Helicobacter pylori Infection
Helicobacter pylori 감염이 있는 건강검진 성인에서 심혈관계 위험 인자 분석
서검석·최석채·최창수·조은영·김지웅·김태현·나용호
원광대학교 의과대학 내과학교실, 소화기병연구소
Abstract
Background/Aims: An association between Helicobacter pylori (H. pylori) infection and cardiovascular disease has been suggested. Especially, C-reactive protein, leukocyte count and lipid profiles have been found to have associations with cardiovascular risk factors in H. pylori infected adults, but epidemiological studies have provided conflicting results. The present study investigated whether gastric H. pylori infection is associated with cardiovascular risk factors in health screeing adults. Methods: The study comprised of 163 adults aged 20∼70 years old who attended health examinations at Wonkwang University Hospital between July 2005 and November 2005. H. pylori infection was identified by CLO test and histology. Results: A total of 60% of participants were positive for the H. pylori test. The H. pylori infection was highest in the age group below 40 years old. Male adults tended to be more frequenthy infected with H. pylori than female adults. Male adults showed higher mean values for WBC, CRP, triglyceride and lower mean values for HDL-cholesterol than female. After adjusting for smoking and alcohol drinking, male adults have higher mean values for WBC and triglyceride level (p<0.05). In contrary, female adults showed higher level of high-density lipoprotein (p=0.002). H. pylori-positive group showed higher mean values for WBC than negative group (p=0.016). But, H. pylori infection had no influence on baseline serum lipid, glucose, CRP and BMI level. Conclusions: H. pylori infection male adults are associated with increased WBC count, a cardiovascular risk factor. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2006;6:18-22)
Key Words: Helicobacter pylori, Cardiovascular disease, Cardiovascular risk factor


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