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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2006;6(1):11-17.
Published online June 1, 2006.
Effect of CYP2C19 Genotype on the Eradication Rate of Helicobacter pylori Infection by Pantoprazole Based Triple Therapy in Korea
CYP2C19 유전자형이 Pantoprazole 포함 삼제 요법에서 Helicobacter pylori 제균 효과에 미치는 영향
신윤선·최명규·오정환·권정현 백창렬·박재명·조유경·이인석 김상우·동미숙*·정인식
가톨릭대학교 의과대학 내과학교실, 고려대학교 생명과학대학*
Abstract
Backgrounds/Aims: CYP2C19 polymorphism has an important role in the metabolism of proton pump inhibitors. The aim of this study was to investigate the effect of CYP2C19 genotype on the eradication rate of Helicobacter pylori (H. pylori) by a pantoprazole based triple therapy. Methods: A total of 251 patients infected with H. pylori were treated with 40 mg of pantoprazole, 500 mg of clarithromycin and 1,000 mg of amoxicillin twice daily for 7 or 10 days. The CYP2C19 genotype was determined with the polymerase chain reaction- restriction fragment length polymorphism analysis. Results: Eradication rates for H. pylori were 84.8%, 80.5% and 84.1% in the homozygous extensive, heterozygous extensive and poor metabolizer groups, respectively. However, CYP2C19 genotypes would be an important factor for treatment failure when the patients were infected with clarithromycin-resistant strains of H. pylori. Female, smoking, gastritis and clarithromycin-resistance were identified as risk factors for treatment failure (p<0.05). Multiple logistic regression analysis revealed endoscopic diagnosis as a significant independent risk factor for treatment failure. Conclusions: The eradication rates of H. pylori by pantoprazole based triple therapy were not significantly different among the CYP2C19 genotypes except in patients infected with clarithromycin-resistant strains. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2006;6:11-17)
Key Words: CYP2C19, Helicobacter pylori, Pantoprazole


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