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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2006;6(2):145-149.
Published online December 9, 2006.
A Case of Activated Crohn's Disease with Acute Duodenal Ulcer Bleeding after NSAID Use
비스테로이드성 소염진통제 복용 후 급성 십이지장 궤양 출혈로 악화된 크론병 1예
송현주·심기남·유금혜·염혜정·김성은·김태헌·정성애·유권·문일환
이화여자대학교 의과대학 내과학교실, 의과학연구소
Abstract
Crohn's disease (CD) is a systemic granulomatous disease that may involve any part of the alimentary tract. CD is more common in the terminal ileum and right colon, but rare (only 0.5∼4.0%) in duodenum. Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce prostaglandin production by inhibiting the activation of cyclooxygenase enzyme and have usually been used for arthritis and arthralgia. Inhibition of prostaglandin synthesis not only contributes to the generation of ulcers in the upper gastrointestinal tract, but it can also exacerbate mucosal injury in the small intestine and colon and cause reactivation of quiescent CD. Herein, we report on a case of activated CD with acute massive duodenal ulcer bleeding after NSAID use, and we include a review of the relevant literatures. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2006;6:145-149)
Key Words: Crohn's disease, Duodenal ulcer bleeding, Nonsteroidal anti-inflammatory drug
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