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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2007;7(1):20-25.
Published online June 1, 2007.
Efficacy and Safety of Standard Triple Therapy of Helicobacter pylori Eradication in Patients with Chronic Kidney Disease
만성신장병 환자에서 헬리코박터 제균 표준 삼제 요법의 효과 및 안전성
강민정·심기남·백수정·오희정·정지민·나윤주·김성은·정성애·유 권
이화여자대학교 의과대학 내과학교실, 의과학연구소
Abstract
Background/Aims: The efficacy of triple therapy for the eradication of Helicobacter pylori (H. pylori) has been documented in patients with normal renal function. The purpose of this study was to investigate the efficacy of proton pump inhibitor (PPI)-based triple eradication therapy in chronic kidney disease (CKD) patients with H. pylori infection. Methods: This study included 18 patients with CKD (GFR <60 mL/min/1.73 m2 for more than 3 months, irrespective of the presence or absence of kidney damage) and 18 age and sex-matched patients with normal creatinine group (control), who had peptic ulcer disease with H. pylori infection. We evaluated the efficacy and the safety of the regimens including PPI-based triple therapy for H. pylori eradication, retrospectively. The combination of omeprazole 20 mg, amoxicillin 1,000 mg, and clarithromycin 500 mg, all twice daily, was used for 1 week, mainly. Eradication of H. pylori was checked by means of histology, rapid urease test, or 13C urea breath test, 4∼8 weeks after the eradication therapy. Results: All except 1 patient (1 patient, CKD group) had successful eradication of H. pylori (94.4%, CKD group vs. 100%, control group). For the CKD patients, the glomerular filtration rate after eradication therapy remained unchanged after the one month of H. pylori eradication (33.3⁑8.6 mL/min/1.73 m2 vs. 34.1⁑10.8 mL/min/1.73 m2, p=0.60). Conclusions: The PPI-based triple therapy for H. pylori eradication in the CKD patients was as efficacious as control group, without adverse effect on renal function. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2007;7:20-25)
Key Words: Chronic kidney disease, Helicobacter pylori, Eradication


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