| Meta-analysis of the H. pylori Eradication Rates according to the Duration of the First-line Therapy |
| Helicobacter pylori 일차 제균 치료에서 프로톤 펌프 억제제 포함 삼제 요법의 투여 기간에 따른 제균율 비교: 국내 보고의 메타 분석 |
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정해선ㆍ심기남ㆍ박혜숙*ㆍ강민정ㆍ정지민ㆍ하창윤ㆍ나윤주ㆍ백수정ㆍ김성은ㆍ정성애ㆍ유권ㆍ문일환 |
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이화여자대학교 의과대학 내과학교실, 예방의학교실*, 의과학연구소 |
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| Abstract |
Background/Aims
PPI-based triple therapy using amoxicillin, clarithromycin is the standard first-line regimen for eradication of Helicobacter pylori in Korea. Since the optimal duration of the therapy is debatable, we conducted this study to compare the eradication rates based on different treatment durations of triple therapy. Methods: We analyzed two abstracts and six articles published from 1996 to 2007 in Korea, to compare the eradication rates, according to the treatment duration, i.e., 7, 10, and 14 days using Mantel- Haenszel methods. Results: The odds ratio comparing the eradication rates based on different treatment durations was 1.91 in 7 vs. 14 days, 1.49 in 7 vs. 10 days and 1.86 in 10 vs. 14 days. The eradication rate of only 14 days treatment showed more than 90% by per protocol analysis. Conclusions: The eradication rate of 14 days treatment was higher than that of 7 and 10 days. A longer duration of therapy resulted in a higher eradication rate. However, considering the limit of metaanalysis, we should deliberate prolongation of the treatment duration of the first line Helicobacter pylori eradication therapy prudently. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2008;8:9-14) |
| Key Words:
Helicobacter pylori, Eradication, Triple therapy, Metaanalysis |
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