| The Clinical Usefulness of the Non-invasive Rapid Urine Test to Helicobacter pylori: RAPIRUNⓇ |
| Helicobacter pylori 요 항체 검출 방법인 RAPIRUNⓇ 검사의 유용성 |
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김진일ㆍ정대영ㆍ장우임ㆍ조세현ㆍ박수헌ㆍ한준열ㆍ김재광ㆍ한석원ㆍ정인식 |
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가톨릭대학교 의과대학 내과학교실 |
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| Abstract |
Background/Aims
The aim of this study was to evaluate the diagnostic accuracy of RAPIRUNⓇ test in clinical practice. Methods: A set of H. pylori tests which were composed of endoscopic biopsy, 13C-urea breath test (13C-UBT), serum IgG-ELISA, and urine anti-H. pylori IgG test was conducted on 204 patients on the same day. The prevalence of H. pylori was calculated using each test independently. Results: The proportion of positive result of H. pylori test was 59.3%, 56.4%, 57.4%, and 50.5% with gastric mucosal biopsy, 13C-UBT, serum IgG-ELISA, and rapid urine RAPIRUNⓇ test, respectively. With gastric mucosal biopsy, 13C-UBT, and serum IgG-ELISA as the gold standard, a patient was considered to be H. pylori positive when all three tests were positive, or H. pylori negative when all were negative. The sensitivity, specificity, positive and negative predictive value, and accuracy of the rapid urine RAPIRUNⓇ test were 83.5%, 98.3%, 98.7%, 79.4%, and 89.3%, respectively. Conclusions: Urine based RAPIRUNⓇ test for detection of anti-H. pylori antibody was an accurate test, especially in specificity. With the advantage of easiness, rapidity, and non-invasiveness of RAPIRUNⓇ test, we expect that RAPIRUNⓇ test would be useful in general practice for H. pylori screening. |
| Key Words:
H. pylori, RAPIRUN&; #9415; , Urine ELISA |
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