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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2008;8(2):82-90.
Published online December 10, 2008.
Gastric Mucosal Cytokines, Matrix Metalloproteinase 3, and Pepsinogen Secretion before and after Helicobacter pylori Eradication in Gastroduodenal Phenotypes
양성 위십이지장 질환에서 Helicobacter pylori 제균 전후의 위점막 싸이토카인, Matrix Metalloproteinase 3, Pepsinogen 농도
황보영ㆍ장영운ㆍ오형철*ㆍ장재영ㆍ심재준ㆍ이상욱ㆍ하승형ㆍ이영주ㆍ유전수ㆍ김효종ㆍ김병호ㆍ장린
경희대학교 의과대학 소화기내과학교실, 중앙대학교 의과대학 소화기내과학교실*
Abstract
Background/Aims
Relations between host genetic factors and clinical outcomes of Helicobacter pylori (H. pylori) infection are variable among ethnicities. This present study was to examine gastric mucosal cytokines, matrix metalloproteinase (MMP)-3, and serum pepsinogen levels before and after eradication of H. pylori according to Interleukin (IL)-1B genotypes and benign gastroduodenal phenotypes in a Korean population. Methods: A total of 349 Koreans including H. pylori-infected subjects (n=230) and H. pylori- negative controls (n=119) were enrolled. The former groups were classified into groups according to the presence of non-atrophic gastritis (NAG, n=74), atrophic gastritis (AG, n=56), gastric ulcer (GU, n=37), and duodenal ulcer (DU, n=63). IL-1B polymorphisms were genotyped by PCR-RFLP. Gastric mucosal IL-1β, IL-8 and MMP-3, and serum pepsinogen I and II levels were measured by ELISA and radioimmunoassay, respectively. Results: There were no significant differences between the IL-1B-31/-511 haplotype (TT/CC, CT/CT, and CC/TT) frequencies among the H. pylori-positive and negative groups. The genotypes of IL-1B-31/-511 polymorphisms did not affect clinical phenotypes, inflammatory cytokines, MMP-3, and pepsinogen secretion. Subjects with H. pylori-infected atrophic gastritis exhibited significantly higher basal levels of cytokines and a lower pepsinogen I/II ratio than those of other groups. Following H. pylori eradication, inflammatory cytokines significantly decreased and the pepsinogen I/II ratio increased in all groups. Conclusions: Mucosal inflammatory cytokines, MMP-3, and pepsinogen secretion are related to gastroduodenal phenotypes but not IL-1B genotypes. Eradication of H. pylori can reduce mucosal inflammation and restore pepsinogen secretion. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2008;8:82-90)
Key Words: Helicobacter pylori, IL-1B genotypes, Gastroduodenal phenotypes


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