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The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2009;9(1):31-35.
Published online July 10, 2009.
Usefulness of Serum Pepsinogen Test for Detection of Atrophic Gastritis in Health Check-Up Population
건강 검진자에서 위축성 위염의 선별을 위한 혈청 Pepsinogen 검사의 유용성
강정묵ㆍ양종인ㆍ박민정ㆍ김동희ㆍ김충현ㆍ김나영*ㆍ정현채ㆍ송인성
서울대학교병원 강남헬스케어센터, 분당서울대학교병원*, 서울대학교 의과대학 내과학교실, 간연구소
Abstract
Background/Aims
This study was performed to determine whether serum pepsinogen (PG) can be used to detect atrophic gastritis (AG). Methods: AG was evaluated by endoscopy in 2,400 subjects. Serum PG I, II, and Helicobacter pylori IgG were measured. The risk of AG was evaluated in the relation to these markers. Results: The best cut off value of the PG I/II for the AG was 4.0 with sensitivity of 50.3% and specificity of 72.0%. In univariate analysis, male, old age (>50), positive for H. pylori, and low PG were associated with AG. In multivariate analysis, both positivity for H. pylori (OR 2.59, 95% CI 2.17∼3.10) and low PG (OR 2.81, 95% CI 2.22∼3.56) were associated with AG. After subjects were classified into four groups based on H. pylori antibody and the level of PG, the risk of AG was highest in the H. pylori-positive, low PG group with an OR of 4.87 (95% CI: 3.74∼6.33). Conclusions: PG I/II ratio (≤4) was found to be reliable marker for the detection of AG. Patients with positive PG test who were positive for H. pylori IgG constitute a high-risk group for AG and a good candidate for endoscopic screening for gastric cancer. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2009;9:31-35)
Key Words: Pepsinogen, Helicobacter pylori, Atrophic gastritis


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