The Eradication Rate of <i>Helicobacter pylori </i>Using PPI-based Triple Therapy in Jeju Island

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2009;9(1):26-30.
Published online July 10, 2009.

The Eradication Rate of Helicobacter pylori Using PPI-based Triple Therapy in Jeju Island

프로톤펌프 억제제 근간의 3제 요법에 의한 제주 지역 Helicobacter pylori 제균율

김흥업ㆍ송현주ㆍ최은광ㆍ조유경ㆍ송병철

제주대학교 의학전문대학원 내과학교실

Abstract

Background/Aims
There has been few data for the eradication rate of triple therapy (proton pump inhibitor, amoxicillin, clarithromycin) to H. pylori in Jeju. We performed this study to determine the eradication rate of PPI-based triple therapy and the factors influencing the eradication rate in Jeju island. Methods: We retrospectively reviewed the medical record of those whom treated with PPI-based triple therapy for H. pylori infection and had follow-up study for the eradication from January 2005 to August 2007. Results: Among total 523 patients, 169 patients were excluded due to follow-up loss. Of the remained 354 patients (the mean age: 57±15), male and female were 228 and 126, respectively. The total eradication rate was 68.6% (243/354). There were no significant differences of H. pylori eradication rate among the age group, sex, residence area, and the activity of peptic ulcers. However, the eradication rates were higher in the duodenal ulcer group than gastric ulcer group (77.4% vs. 64.9%) (p=0.021), and 2 weeks treatment group than 1 week treatment group (86.2% vs. 64.6%) (p=0.001). Conclusions: The eradication rate of PPI based triple therapy was 68.6% in Jeju island, and 2 weeks treatment group showed significant higher eradication rate compared to 1 week treatment group. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2009;9:26-30)

Key Words: Helicobacter pylori, PPI-based triple therapy, Eradication rate, Jeju island