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Korean J Helicobacter  Up Gastrointest Res > Volume 17(4); 2017 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2017;17(4):185-189.
DOI: https://doi.org/10.7704/kjhugr.2017.17.4.185    Published online December 10, 2017.
Sedation-related Adverse Events Associated with a Diagnostic Upper Endoscopy: A Single Center-observational Study
Jihyun Lee, Ki Nam Shim, Kang Hoon Lee, Ko Eun Lee, Ji Young Chang, Chung Hyun Tae, Chang Mo Moon, Seong Eun Kim, Hye Kyung Jung, Sung Ae Jung
Department of Internal Medicine, Ewha Medical Research Institute, College of Medicine, Ewha Womans University, Seoul, Korea. shimkn@ewha.ac.kr
진단 목적의 상부위장관 내시경에서의 진정 관련 이상 반응: 단일 기관의 관찰 연구
이지현, 심기남, 이강훈, 이고은, 장지영, 태정현, 문창모, 김성은, 정혜경, 정성애
이화여자대학교 의과대학 내과학교실 및 의과학연구소
Received: 24 July 2017   • Revised: 18 August 2017   • Accepted: 19 August 2017
Appropriate sedation during endoscopy can significantly reduce the discomfort experienced by a patient when the procedure is performed; however, it is associated with several potential risks. Very few reports describe sedation-related adverse events occurring during endoscopy. Our study evaluated the current status of sedation-related adverse events during a diagnostic upper endoscopy. MATERIALS AND METHODS: We reviewed medical records of 5,564 cases of diagnostic upper endoscopy performed using midazolam for sedation at the Ewha Womans University, Mokdong Hospital, between January 2015 and March 2016. RESULTS: Among the 5,564 cases, sedation-related adverse events were reported in 56 cases (1.0%). Among these 56 patients, 30 patients (53.6.%) were men and 26 patients (46.4%) were women. Mean age of the patients was 63.7±15.4 years. The most common adverse event reported was hypoxia, which was observed in 37 patients (0.7%). Other adverse events included sedation failure (18 patients, 0.3%) and delayed discharge from the recovery room due to delayed recovery of consciousness (one patient, 0.02%). Among patients presenting with hypoxia, 35 patients recovered after administration of intravenous flumazenil and oxygen via nasal prongs. Administration of oxygen alone helped recovery in 2 patients. All patients recovered uneventfully with no mortalities registered. CONCLUSIONS: Our study showed that the use of sedative midazolam is relatively safe during an upper endoscopy. The rate of occurrence of adverse events was very low, and no fatal adverse events were observed. However, close observation and continuous monitoring is an essential component of safe sedation during endoscopy.
Key Words: Adverse events; Conscious sedation; Endoscopy
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