Chemoprevention of Gastric Cancer: Statins

Choi, Sang Hyeon; Baik, Gwang Ho

doi:2017.17.4.175

Korean J Helicobacter Up Gastrointest Res > Volume 17(4); 2017 > Article

Review

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2017;17(4):175-178.
DOI: https://doi.org/10.7704/kjhugr.2017.17.4.175 Published online December 10, 2017.

Chemoprevention of Gastric Cancer: Statins

Sang Hyeon Choi, Gwang Ho Baik

Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea. baikgh@hallym.or.kr

위암의 화학 예방 요법: 스타틴

최상현, 백광호

한림대학교 의과대학 춘천성심병원 내과학교실

Correspondence: Gwang Ho Baik,
Email: baikgh@hallym.or.kr

Received: 1 October 2017 • Revised: 30 October 2017 • Accepted: 31 October 2017

Abstract

Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the enzyme involved in the rate-limiting step in cholesterol synthesis. Several studies have shown that statins have potential protective effects against gastric cancer; however, other studies have reported contradictory results. Therefore, further studies are needed to clarify the role of statins in the chemoprevention of gastric cancer.

Key Words: Chemoprevention; Hydroxymethylglutaryl-CoA reductase inhibitors; Stomach neoplasms