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Korean J Helicobacter  Up Gastrointest Res > Volume 17(4); 2017 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2017;17(4):175-178.
DOI: https://doi.org/10.7704/kjhugr.2017.17.4.175    Published online December 10, 2017.
Chemoprevention of Gastric Cancer: Statins
Sang Hyeon Choi, Gwang Ho Baik
Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea. baikgh@hallym.or.kr
위암의 화학 예방 요법: 스타틴
최상현, 백광호
한림대학교 의과대학 춘천성심병원 내과학교실
Correspondence:  Gwang Ho Baik,
Email: baikgh@hallym.or.kr
Received: 1 October 2017   • Revised: 30 October 2017   • Accepted: 31 October 2017
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the enzyme involved in the rate-limiting step in cholesterol synthesis. Several studies have shown that statins have potential protective effects against gastric cancer; however, other studies have reported contradictory results. Therefore, further studies are needed to clarify the role of statins in the chemoprevention of gastric cancer.
Key Words: Chemoprevention; Hydroxymethylglutaryl-CoA reductase inhibitors; Stomach neoplasms

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