| Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma |
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Jin Tae Jung |
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Department of Internal medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. jungjt@cu.ac.kr |
| Helicobacter pylori 음성 위 Mucosa-associated Lymphoid Tissue 림프종 |
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정진태 |
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대구가톨릭대학교 의과대학 내과학교실 |
Correspondence:
Jin Tae Jung,
Email: jungjt@cu.ac.kr
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Received: 23 June 2017 • Revised: 30 June 2017 • Accepted: 16 July 2017 |
| Abstract |
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Approximately 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and 10% of gastric MALT lymphomas occur independent of H. pylori infection. The gene translocation t(11;18)(q21;q21) is frequently observed in cases presenting with H. pylori-negative gastric MALT lymphomas. H. pylori-negative gastric MALT lymphomas do not differ from H. pylori-positive gastric MALT lymphomas in terms of clinical features and endoscopic findings and show similar prognosis. H. pylori eradication therapy could be considered as first-line treatment for gastric MALT lymphomas regardless of their H. pylori infection status. In cases with H. pylori-negative gastric MALT lymphomas, the rate of response to eradication therapy varies from 0 to 83%. If gastric MALT lymphoma persists for more than a year, secondary treatment with radiotherapy, chemotherapy, and/or surgery should be considered. Of note, the comparative outcome is excellent. |
| Key Words:
Helicobacter pylori; Lymphoma; B-cell; marginal zone |
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