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Korean J Helicobacter  Up Gastrointest Res > Volume 17(3); 2017 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2017;17(3):122-126.
DOI: https://doi.org/10.7704/kjhugr.2017.17.3.122    Published online September 10, 2017.
Helicobacter pylori-negative Gastric Mucosa-associated Lymphoid Tissue Lymphoma
Jin Tae Jung
Department of Internal medicine, Catholic University of Daegu School of Medicine, Daegu, Korea. jungjt@cu.ac.kr
Helicobacter pylori 음성 위 Mucosa-associated Lymphoid Tissue 림프종
대구가톨릭대학교 의과대학 내과학교실
Correspondence:  Jin Tae Jung,
Email: jungjt@cu.ac.kr
Received: 23 June 2017   • Revised: 30 June 2017   • Accepted: 16 July 2017
Approximately 90% of gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and 10% of gastric MALT lymphomas occur independent of H. pylori infection. The gene translocation t(11;18)(q21;q21) is frequently observed in cases presenting with H. pylori-negative gastric MALT lymphomas. H. pylori-negative gastric MALT lymphomas do not differ from H. pylori-positive gastric MALT lymphomas in terms of clinical features and endoscopic findings and show similar prognosis. H. pylori eradication therapy could be considered as first-line treatment for gastric MALT lymphomas regardless of their H. pylori infection status. In cases with H. pylori-negative gastric MALT lymphomas, the rate of response to eradication therapy varies from 0 to 83%. If gastric MALT lymphoma persists for more than a year, secondary treatment with radiotherapy, chemotherapy, and/or surgery should be considered. Of note, the comparative outcome is excellent.
Key Words: Helicobacter pylori; Lymphoma; B-cell; marginal zone

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