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Korean J Helicobacter  Up Gastrointest Res > Volume 17(3); 2017 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2017;17(3):118-121.
DOI: https://doi.org/10.7704/kjhugr.2017.17.3.118    Published online September 10, 2017.
Helicobacter pylori-negative Gastric Cancer
Jin Seok Jang
Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea. jsjang@dau.ac.kr
Helicobacter pylori 음성 위암
동아대학교 의과대학 내과학교실
Correspondence:  Jin Seok Jang,
Email: jsjang@dau.ac.kr
Received: 19 July 2017   • Revised: 23 August 2017   • Accepted: 23 August 2017
Although Helicobacter pylori is considered the main etiological factor in gastric cancer, at least 5.4% of gastric cancer cases in South Korean patients are H. pylori-negative. However, false-negative H. pylori results should be considered. The definitions of H. pylori status in patients with atrophic gastritis but negative tests for H. pylori are variable. Inaccurate H. pylori detection systems can interfere with interpretation of the results. Even when H. pylori has been eradicated, gastric atrophy and intestinal metaplasia resulting from long-term colonization can occur. It is very difficult to determine whether patients with gastric cancer, who frequently have advanced gastric atrophy and intestinal metaplasia, have had previous H. pylori infection based on invasive tests. In addition, H. pylori-negative gastric cancers present with a more advanced pT classification and a more advanced stage than H. pylori-positive gastric cancers. Negative H. pylori status appears to be an indicator of poor prognosis in patients with gastric cancer, and is independent of other well-known clinical and pathologic prognostic variables.
Key Words: Gastric cancer; Helicobacter pylori; Negativity; Prognosis

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