| Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma |
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Jung Bin Yoon, Gwang Ha Kim, Do Youn Park, Young Geum Kim, Sung Ik Pyeon, Bong Eun Lee, Geun Am Song |
1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. doc0224@pusan.ac.kr
2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
3Department of Pathology, Pusan National University School of Medicine, Busan, Korea. |
| 간세포양 샘암종의 임상병리학적 특성 |
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윤정빈1,2, 김광하1,2, 박도윤3, 김영금3, 편성익1,2, 이봉은1,2, 송근암1,2 |
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부산대학교 의학전문대학원 내과학교실1, 부산대학교병원 의생명연구원2, 부산대학교 의학전문대학원 병리학교실3 |
Correspondence:
Gwang Ha Kim,
Email: doc0224@pusan.ac.kr
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Received: 3 March 2017 • Revised: 28 March 2017 • Accepted: 29 March 2017 |
| Abstract |
BACKGROUND/AIMS
Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histology resembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to early lymph node or liver metastasis, but information concerning GHA is still limited. Therefore, we aimed to evaluate the clinicopathological features of GHA. MATERIALS AND METHODS: We reviewed the medical records of 9 patients who were diagnosed as having GHA between January 2011 and December 2016. The clinicopathological characteristics of these patients were retrospectively analyzed. RESULTS: The median age of the patients at diagnosis was 68.9 years. Seven of the 9 patients were male. Serum AFP levels were elevated in 3 of 4 patients. All the tumors were >4 cm (range, 4~12 cm), and 7 tumors were located at the lower third of the stomach. Five tumors were classified as Borrmann's type 3, with a purple, berry-like surface. Of the 6 patients without distant metastasis, 5 received curative-intent surgery and 3 received adjuvant chemotherapy. Three patients with distant metastasis received either palliative operation and/or chemotherapy. Their median survival time was 11.8 months (range, 1~36 months). Two patients with elevated serum CEA levels had poor outcomes. CONCLUSIONS: GHA is a rare subtype of gastric cancer that is prone to liver metastasis. All GHAs are advanced gastric cancer with a purple, berry-like surface at diagnosis. Although the prognosis of advanced-stage GHA is poor, active multimodality treatment might provide some benefit. |
| Key Words:
Adenocarcinoma; Chemotherapy; Endoscopy; Hepatocelluar carcinoma; Stomach |
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