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Korean J Helicobacter  Up Gastrointest Res > Volume 17(2); 2017 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2017;17(2):88-93.
DOI: https://doi.org/10.7704/kjhugr.2017.17.2.88    Published online June 10, 2017.
Clinicopathological Characteristics of Gastric Hepatoid Adenocarcinoma
Jung Bin Yoon, Gwang Ha Kim, Do Youn Park, Young Geum Kim, Sung Ik Pyeon, Bong Eun Lee, Geun Am Song
1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. doc0224@pusan.ac.kr
2Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.
3Department of Pathology, Pusan National University School of Medicine, Busan, Korea.
간세포양 샘암종의 임상병리학적 특성
윤정빈1,2, 김광하1,2, 박도윤3, 김영금3, 편성익1,2, 이봉은1,2, 송근암1,2
부산대학교 의학전문대학원 내과학교실1, 부산대학교병원 의생명연구원2, 부산대학교 의학전문대학원 병리학교실3
Correspondence:  Gwang Ha Kim,
Email: doc0224@pusan.ac.kr
Received: 3 March 2017   • Revised: 28 March 2017   • Accepted: 29 March 2017
Gastric hepatoid adenocarcinoma (GHA), a rare type of primary gastric cancer, is characterized by a histology resembling hepatocellular carcinoma. Previous case studies reported that patients with GHA have a poor prognosis due to early lymph node or liver metastasis, but information concerning GHA is still limited. Therefore, we aimed to evaluate the clinicopathological features of GHA. MATERIALS AND METHODS: We reviewed the medical records of 9 patients who were diagnosed as having GHA between January 2011 and December 2016. The clinicopathological characteristics of these patients were retrospectively analyzed. RESULTS: The median age of the patients at diagnosis was 68.9 years. Seven of the 9 patients were male. Serum AFP levels were elevated in 3 of 4 patients. All the tumors were >4 cm (range, 4~12 cm), and 7 tumors were located at the lower third of the stomach. Five tumors were classified as Borrmann's type 3, with a purple, berry-like surface. Of the 6 patients without distant metastasis, 5 received curative-intent surgery and 3 received adjuvant chemotherapy. Three patients with distant metastasis received either palliative operation and/or chemotherapy. Their median survival time was 11.8 months (range, 1~36 months). Two patients with elevated serum CEA levels had poor outcomes. CONCLUSIONS: GHA is a rare subtype of gastric cancer that is prone to liver metastasis. All GHAs are advanced gastric cancer with a purple, berry-like surface at diagnosis. Although the prognosis of advanced-stage GHA is poor, active multimodality treatment might provide some benefit.
Key Words: Adenocarcinoma; Chemotherapy; Endoscopy; Hepatocelluar carcinoma; Stomach

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