<i>Helicobacter pylori</i> Eradication Rate in Patients with Diabetes

Yoo, Jiyeon; Yu, Yeong Ji; Cho, Gumin; Oh, Hongkwon; Oh, Seung Hyun; Kim, Tae Ho; Oh, Jung Hwan

doi:2017.17.2.83

Korean J Helicobacter Up Gastrointest Res > Volume 17(2); 2017 > Article

Original Article

The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2017;17(2):83-87.
DOI: https://doi.org/10.7704/kjhugr.2017.17.2.83 Published online June 10, 2017.

Helicobacter pylori Eradication Rate in Patients with Diabetes

Jiyeon Yoo, Yeong Ji Yu, Gumin Cho, Hongkwon Oh, Seung Hyun Oh, Tae Ho Kim, Jung Hwan Oh

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. ojh@catholic.ac.kr, kimtaeho@catholic.ac.kr

당뇨병 환자에서 Helicobacter pylori 제균 성공률: 당뇨병 없는 환자와 비교하여

유지연, 유영지, 조규민, 오홍권, 오승현, 김태호, 오정환

가톨릭대학교 의과대학 내과학교실

Correspondence: Tae Ho Kim,
Email: kimtaeho@catholic.ac.kr
Jung Hwan Oh,
Email: ojh@catholic.ac.kr

Received: 20 January 2017 • Revised: 15 March 2017 • Accepted: 17 March 2017

Abstract

BACKGROUND/AIMS
The prevalence of diabetes mellitus is increasing. Little is known about the difference in Helicobacter pylori eradication rates between diabetic patients and non-diabetics. The aim of this study was to compare the eradication rate between diabetic and non-diabetic patients. MATERIALS AND METHODS: The medical records of patients who received a proton pump inhibitor (PPI)-based eradication therapy between 2012 and 2015 were retrospectively reviewed. All the patients underwent endoscopic biopsy to confirm H. pylori infection. Successful eradication was confirmed by using the ¹³C-urea breath test, biopsy, or rapid urease test, which was performed at least 4 weeks after the end of eradication therapy. RESULTS: A total of 1,402 patients were included. The eradication rate was 74.3% (1,041/1,402; 95% CI, 72.0~76.5%). Excluding 151 patients who were confirmed to have no diabetes, 182 diabetic and 1,069 non-diabetic patients were compared. No significant difference (P=0.667) in eradication rate with PPI-amoxicillin-clarithromycin therapy was found between the diabetic (75.8%, 138/182; 95% CI, 69.6~82.0%) and non-diabetic groups (74.0%, 791/1,069; 95% CI, 71.4~76.6%). Peptic ulcer was much more common in the diabetic group than in the non-diabetic group (67.0% vs. 57.9%, P=0.038). CONCLUSIONS: The H. pylori eradication rate with PPI-based triple therapy in the diabetic patients was probably not different from that in non-diabetic patients.

Key Words: Diabetes mellitus; Helicobacter pylori; Prevalence; Retrospective studies