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Korean J Helicobacter  Up Gastrointest Res > Volume 18(4); 2018 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2018;18(4):231-234.
DOI: https://doi.org/10.7704/kjhugr.2018.18.4.231    Published online December 10, 2018.
Pharmacological Treatment for Peptic Ulcer Bleeding
Dae Won Ma  , Byung Wook Kim 
Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea. gastro@catholic.ac.kr
소화성 궤양 출혈의 약물 치료
마대원, 김병욱
가톨릭대학교 의과대학 인천성모병원 내과학교실
Correspondence:  Byung Wook Kim, Tel: +82-32-280-5052, Fax: +82-32-280-5987, 
Email: gastro@catholic.ac.kr
Received: 28 May 2018   • Revised: 13 June 2018   • Accepted: 4 July 2018
Abstract
Peptic ulcer bleeding (PUB) is the most common cause of non-variceal upper gastrointestinal bleeding, and its frequency has been declining over the past decades. However, mortality from PUB persists, and it is still a serious challenge in clinical practice. Although endoscopic intervention is the basic treatment modality for PUB, pharmacological therapy is an important adjunct. The emergence of proton pump inhibitors (PPIs) enables maintenance of intragastric pH >6, which greatly helps in the treatment of PUB. Continuous intravenous infusion of high-dose PPI reduces the re-bleeding rate, thereby helping avoid additional surgery in patients with high-risk stigmata. Moreover, administration of PPIs prior to endoscopy may reduce the need for additional endoscopic intervention. Recently introduced gastric acid suppressants, such as potassium-competitive acid blockers, have shown promising results in further treatment of PUB.
Key Words: Peptic ulcer bleeding; Pharmacological therapy; Proton pump inhibitor


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