Chemoprevention of Gastric Cancer: Statins |
Sang Hyeon Choi, Gwang Ho Baik |
Department of Internal Medicine, Hallym University Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea. baikgh@hallym.or.kr |
위암의 화학 예방 요법: 스타틴 |
최상현, 백광호 |
한림대학교 의과대학 춘천성심병원 내과학교실 |
Correspondence:
Gwang Ho Baik, Email: baikgh@hallym.or.kr |
Received: 1 October 2017 • Revised: 30 October 2017 • Accepted: 31 October 2017 |
Abstract |
Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Because the gastric cancer-related mortality rate is expected to increase, chemo-preventive strategies for gastric cancer are required. Statins inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, the enzyme involved in the rate-limiting step in cholesterol synthesis. Several studies have shown that statins have potential protective effects against gastric cancer; however, other studies have reported contradictory results. Therefore, further studies are needed to clarify the role of statins in the chemoprevention of gastric cancer. |
Key Words:
Chemoprevention; Hydroxymethylglutaryl-CoA reductase inhibitors; Stomach neoplasms |
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