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Korean J Helicobacter  Up Gastrointest Res > Volume 18(3); 2018 > Article
The Korean Journal of Helicobacter  and Upper Gastrointestinal Research 2018;18(3):186-197.
DOI: https://doi.org/10.7704/kjhugr.2018.18.3.186    Published online September 10, 2018.
Predictive Factors for Improvement of Atrophic Gastritis and Intestinal Metaplasia: A Long-term Prospective Clinical Study
Young Jae Hwang, Nayoung Kim  , Chang Yong Yun, Min Gu Kwon, Sung Min Baek, Yeong Jae Kwon, Hye Seung Lee, Jae Bong Lee, Yoon Jin Choi, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee
1Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. nayoungkim49@empas.com
2Department of Internal Medicine and Institute of Liver Research, Seoul National University College of Medicine, Seoul, Korea.
3Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
4Division of Statistics in Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam, Korea.
위축성 위염과 장상피화생의 호전에 영향을 미치는 인자에 대한 전향적 연구
황영재1, 김나영1,2, 윤창용1, 권민구1, 백성민1, 권영재1, 이혜승3, 이제봉4, 최윤진1, 윤  혁1, 신철민1, 박영수1, 이동호1,2
분당서울대학교병원 내과1, 서울대학교 의과대학 내과학교실, 간연구소2, 분당서울대학교병원 병리과3, 의학연구협력센터 통계과4
Correspondence:  Nayoung Kim, Tel: +82-31-787-7008, Fax: +82-31-787-4051, 
Email: nayoungkim49@empas.com
Received: 1 June 2018   • Revised: 21 July 2018   • Accepted: 22 July 2018
Abstract
BACKGROUND/AIMS
To investigate the predictive factors for improvement of atrophic gastritis (AG) and intestinal metaplasia (IM). MATERIALS AND METHODS: A total of 778 subjects were prospectively enrolled and followed up for 10 years. Histological analysis of AG and IM was performed by using the updated Sydney system. To find the predictive factors for reversibility of AG and IM, 24 factors including genetic polymorphisms and bacterial and environmental factors were analyzed. RESULTS: In all subjects, the predictive factor by multivariate analysis for improvement of both antral and corpus AG was successful eradication. The predictive factors for improvement of antral IM were age and successful eradication. The predictive factor for improvement of corpus IM was successful eradication. In patients with Helicobacter pylori infection, age and cagA were predictive factors for improvement of AG and IM. In patients with H. pylori eradication, monthly income and cagA were predictive factors for improvement of AG and IM. CONCLUSIONS: H. pylori eradication is an important predictive factor of regression of AG and IM and would be beneficial for the prevention of intestinal-type gastric cancer. Young age, high income, and cagA are additional predictive factors for improving AG and IM status. Thus, various factors affect the improvement of AG and IM.
Key Words: Atrophic gastritis; Helicobacter pylori; Intestinal metaplasia; Therapeutics


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